Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma  

作　　者：Yuetong Wang Lingyu Sun Jiahui Guo Keqing Shi Luoran Shang Jian Xiao Yuanjin Zhao 

机构地区：[1]Precision Medicine Center Laboratory,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325035,China [2]Department of Clinical Laboratory,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,210008,China [3]Zhongshan-Xuhui Hospital,The Shanghai Key Laboratory of Medical Epigenetics,The International Co-laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,Institutes of Biomedical Sciences,Fudan University,Shanghai,200032,China [4]Research Units of Clinical Translation of Cell Growth Factors and Diseases Research of Chinese Academy of Medical Science,School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,China [5]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing,210096,China

出　　处：《Bioactive Materials》2021年第6期1555-1562,共8页生物活性材料（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060,22002018,81800567 and 61927805);the Natural Science Foundation of Jiangsu(BE2018707);the Launching Funds from Fudan University(JIH1340032 and JIH1340038);the affiliated Zhongshan-Xuhui Hospital(KJK04202000021).

摘　　要：Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia.Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired.In this work,we developed pollens-derived magnetic porous particles as adsorbents for this purpose.The natural pollen grains were modified to obtain high surface porosity,a large inner cavity,magnet responsiveness,and specific wettability.The resultant particles exhibited satisfying performance in the adsorption of a series of oils and organic solvents out of water.Besides,the particles were directly utilized to the adsorption of low-density lipoprotein in plasma,which showed high selectivity,and achieved an outstanding adsorption capacity as high as 34.9%within 2 h.Moreover,their salient biocompatibility was demonstrated through simulative hemoperfusion experiments.These features,together with its abundant source and facile fabrication,makes the pollens-derived magnetic porous particles excellent candidate for low-density lipoprotein-apheresis and water treatment applications.

关 键 词：POLLEN Microporous structure Low-density lipoprotein Oil/water separation Lipid adsorption 

分 类 号：R318[医药卫生—生物医学工程]