白介素-6及血清肿瘤坏死因子-α诊断尖锐湿疣的检验价值  

Diagnostic value of interleukin-6 and serum tumor necrosis factor-α in condyloma acuminata

作　　者：李春燕 袁绍康 LI Chun-yan;YUAN Shao-kang(Dermatology Control Department,Yantai Center for Disease Control and Prevention,Yantai 264000,China)

机构地区：[1]烟台市疾病预防控制中心皮肤病防制科,264000

出　　处：《中国实用医药》2021年第18期71-74,共4页China Practical Medicine

摘　　要：目的分析白介素-6及血清肿瘤坏死因子-α诊断尖锐湿疣的检验价值。方法选取90例尖锐湿疣患者为观察组,选取同期90例来本单位体检健康者为对照组,所有纳入者均在通过空腹静脉采血后,使用酶联免疫吸附法进行血清肿瘤坏死因子-α以及白介素-6的测定。比较两组白介素-6及血清肿瘤坏死因子-α含量。分析白介素-6及血清肿瘤坏死因子-α联合诊断的灵敏度和特异度。比较观察组37例初发者与53例复发者白介素-6及血清肿瘤坏死因子-α含量。结果观察组白介素-6及血清肿瘤坏死因子-α含量分别为(31.01±4.95)、(24.22±4.56)pg/ml,均低于对照组的(45.29±5.86)、(36.68±5.57)pg/ml,差异具有统计学意义(P<0.05)。白介素-6及血清肿瘤坏死因子-α联合诊断的特异度与灵敏度均高于白介素-6及血清肿瘤坏死因子-α单项检测,差异具有统计学意义(P<0.05)。初发者白介素-6及血清肿瘤坏死因子-α含量分别为(39.11±6.02)、(29.12±5.37)pg/ml,均高于复发者的(21.92±3.88)、(20.21±4.28)pg/ml,差异具有统计学意义(P<0.05)。结论在尖锐湿疣的诊断中,尖锐湿疣患者白介素-6及血清肿瘤坏死因子-α含量明显低于健康人群,且初发者白介素-6及血清肿瘤坏死因子-α水平高于复发者,白介素-6及血清肿瘤坏死因子-α联合诊断存在高灵敏度和高特异度,值得临床推广。Objective To analyze the diagnostic value of interleukin-6 and serum tumor necrosis factor-α in condyloma acuminata. Methods There were 90 patients with condyloma acuminata as the observation group, and 90 healthy subjects during the same period as the control group. All enrollees had blood collection through fasting vein, and the serum tumor necrosis factor-α and interleukin-6 were determined by enzyme-linked immunosorbent assay. The interleukin-6 and serum tumor necrosis factor-α were compared between the two groups. The sensitivity and specificity of the combined diagnosis of interleukin-6 and serum tumor necrosis factor-α were analyzed. The interleukin-6 and serum tumor necrosis factor-α of 37 cases of initial onset and 53 cases of relapse in the observation group were compared. Results The interleukin-6 and serum tumor necrosis factor-α of the observation group were(31.01±4.95) and(24.22±4.56) pg/ml, which were lower than(45.29±5.86) and(36.68±5.57) pg/ml of the control group, and the difference was statistically significant(P<0.05). The sensitivity and specificity of the combined diagnosis of interleukin-6 and serum tumor necrosis factor-α were higher than that of interleukin-6 and serum tumor necrosis factor-α alone, and the difference was statistically significant(P<0.05). In the observation group, the interleukin-6 and serum tumor necrosis factor-α of initial onset patients were(39.11±6.02) and(29.12±5.37) pg/ml, which were higher than(21.92±3.88) and(20.21±4.28) pg/ml of relapse cases, and the difference was statistically significant(P<0.05). Conclusion The levels of interleukin-6 and serum tumor necrosis factor-α in patients with condyloma acuminata are significantly higher than those in healthy people, and the levels of interleukin-6 and serum tumor necrosis factor-α of initial onset patients are also lower than those of relapse patients. The combined diagnosis of interleukin-6 and serum tumor necrosis factor-α has high sensitivity and specificity, which is worthy of clinical promo

关 键 词：白介素-6 血清肿瘤坏死因子-Α 尖锐湿疣 灵敏度 特异度 价值 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]