细胞松弛素类天然产物Pericoannosins C-F中间体的合成  

Synthesis of Intermediate of Natural Product of CytochalasinPericoannosins C-F

作　　者：樊一君 刘志波 于芳 Fan Yijun;Liu Zhibo;Yu Fang(School of Petrochemical Engineering,Liaoning Petrochemical University,Fushun Liaoning 113001,China;Fushun Petrochemical Beitian Shunda Company,Fushun Liaoning 113006,China)

机构地区：[1]辽宁石油化工大学石油化工学院,辽宁抚顺113001 [2]抚顺石化北天顺达公司,辽宁抚顺113006

出　　处：《辽宁石油化工大学学报》2021年第3期23-27,共5页Journal of Liaoning Petrochemical University

基　　金：国家自然科学基金项目(21402078)。

摘　　要：PericoannosinsC-F是一种细胞松弛素类天然产物,其结构中包含一个六并六的双环骨架,该骨架单元可以通过一步D-A反应予以构建。对其关键D-A反应所需的中间体进行了合成。在以氟化钾为碱、氧气为氧化剂的条件下,氧化得到所需的羟基后,经过分子内D-A反应全合成PericoannosinsC-F等四个分子。Periconansons C-F is a natural product of cytochalasin.Its structure contains a six and six bicyclic skeleton.We think that we can complete the construction of this skeleton structure through one-step D-A reaction.We synthesized its key D-A reaction intermediate.KF is used as base and O2 is used as oxidant to oxidize the required hydroxyl group.After the intramolecular D-A reaction,it is possible to complete the total synthesis of four molecules,such as percoannosins C-F.

关 键 词：中间体合成 Pericoannosin 细胞松弛素 

分 类 号：TE624[石油与天然气工程—油气加工工程]