海南狗牙花中1个新生物碱  

A new alkaloid from Ervatamia hainanensis

作　　者：李紫薇 桑晨晨 孙彪 田海妍[1] 张晓琦[1,2] 叶文才 LI Zi-wei;SANG Chen-chen;SUN Biao;TIAN Hai-yan;ZHANG Xiao-qi;YE Wen-cai(Institute of Traditional Chinese Medicine&Natural Products,and Guangdong Engineering Research Center for Modernization of Traditional Chinese Medicine(TCM),College of Pharmacy,Jinan University,Guangzhou 510632,China;NMPA Key Laboratory for Quality Evaluation of TCM(Traditional Chinese Patent Medicine),Guangzhou 510632,China)

机构地区：[1]暨南大学药学院 中药及天然药物研究所 广东省现代中药工程技术研究中心,广东广州510632 [2]国家药品监督管理局中成药质量评价重点实验室,广东广州510632

出　　处：《中国中药杂志》2021年第10期2509-2513,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(U1801287,82073712);广东省科技计划项目(2018B020207008,2020B1111110004)。

摘　　要：为了研究海南狗牙花Ervatamia hainanensis枝叶中的生物碱类成分,利用硅胶、Sephadex LH-20、ODS、HPLC等柱色谱分离纯化方法,从海南狗牙花枝叶中分离得到了6个化合物,根据理化性质和波谱数据鉴定了它们的结构,分别为10-hydroxydemethylhirsuteine (1),3R-羟基冠狗牙花碱(3R-hydroxycoronaridine,2),3-(2-羰丙基)-冠狗牙花碱[3-(2-oxopropyl)coronaridine,3],pandine (4),16-epi-vobasine (5),16-epi-vobasinic acid (6)。化合物1为一个新的单萜吲哚类生物碱,化合物5和6为首次从海南狗牙花中分离得到。In order to study the alkaloids from branches and leaves of Ervatamia hainanensis, silica gel, ODS, Sephadex LH-20 and HPLC chromatography were used to obtain six alkaloids from the branches and leaves of E. hainanensis with use of. Based on the physicochemical properties and spectral data, their structures were identified as 10-hydroxydemethylhirsuteine(1), 3R-hydroxycoronaridine(2), 3-(2-oxopropyl)coronaridine(3), pandine(4), 16-epi-vobasine(5), and 16-epi-vobasinic acid(6). Among them, compound 1 was a new monoterpenoid indole alkaloid, and compounds 5 and 6 were obtained from this plant for the first time.

关 键 词：海南狗牙花 单萜吲哚生物碱 化学成分 10-hydroxydemethylhirsuteine 

分 类 号：R284.1[医药卫生—中药学]