定量测定尿促性腺激素判断女童性发育程度的临床研究  

Clinical study on quantitative determination of urinary gonadotropin to determine the sexual development of girls

作　　者：范双 冯小娟 FAN Shuang;FENG Xiaojuan(Department of Pediatrics,Dazu District People’s Hospital,Chongqing 402365,China)

机构地区：[1]大足区人民医院儿科,重庆402365

出　　处：《中国优生与遗传杂志》2021年第2期265-267,共3页Chinese Journal of Birth Health & Heredity

基　　金：大足区科委基金(DZKJ2020ACC1025)。

摘　　要：目的探究定量检测女童尿促性腺激素进而诊断性发育程度的临床意义,便于女童性发育异常筛查的简便法。方法选取2015年12月-2020年12月于大足区人民医院就诊的368例女童进行分析,全部女童均有乳房发育表征,都经过了血清卵泡生成素、Gn RH激发试验、血清促黄体生成素检查,也同期完成了尿促黄体生成素、尿卵泡生成素检查。根据2007年《中枢性(真性)性早熟诊治指南》关于性早熟的诊断标准诊断,受试女童有无性早熟。根据性早熟与否将女童进行分类,包括非性早熟组(230例)与性早熟组(138例)。对比两组女童的尿促黄体生成素与尿卵泡生成素。根据性早熟指南标准诊断结果,就女童的尿促黄体生成素与尿卵泡生成素制作ROC(receiveroperatingcharacteristic)曲线,明确尿促黄体生成素与尿卵泡生成素的左侧拐点,作为诊断的临界值,以此测算尿促黄体生成素、尿卵泡生成素各自或联合数据,作为判断女童性早熟的敏感度与特异度的依据。结果尿促黄体生成素与性早熟组女童尿卵泡生成素高于非性早熟组(P<0.05)。女童尿促黄体生成素与尿卵泡生成素判断性早熟的临界值是5.67 U/mmol与1.60 U/mmol。尿促黄体生成素、尿卵泡生成素单独以及联合判断性早熟的敏感度是:88.41%、76.81%、89.85%,特异度依次对应95.65%、90.43%、96.52%。尿促黄体生成素与尿卵泡生成素同步参考作为判断女童性早熟的可靠性比单一指标参考高。结论尿促黄体生成素、尿卵泡生成素能够简便识别出女童有无性早熟,作为女童健康体检筛查性早熟的依据,极具临床意义。Objective To explore the clinical significance of quantitative detection of urinary gonadotropin in girls for the diagnosis of sexual development,so as to facilitate a simple method for the screening of sexual development abnormalities in girls.Methods a total of 368 girls who visited our hospital from December 2015 to December 2020 were selected for analysis.All the girls had breast development characteristics and had undergone serum follicle-stimulating test,GnRH stimulation test,and serum luteinizing hormone examination.Urine luteinizing hormone and urine follicle-stimulating hormone examination were also completed in the same period.According to the diagnosis and treatment Guide of Central(true)sexual precocity in 2007 on the diagnostic criteria of sexual precocity,the girl tested had sexual precocity.Girls were classified according to whether they had precocious puberty or not,including non-precocious puberty(230 cases)and precocious puberty(138 cases).Urinary luteinizing hormone(luteinizing hormone)and urinary follicular generating hormone(FOLLICle generating hormone)were compared between the two groups.According to the results of the standard in the diagnosis of precocious puberty guide is girl?s urine luteinizing hormone and follicle hormone production of ROC curve,clear urine luteinizing hormone and follicle hormone to the left of a turning point,as the critical value of diagnosis,to measure urine luteinizing hormone,follicle hormone respective or joint data,as the sensitivity of the precocious puberty with a specific degree of the girls.Results Urinary luteinizing hormone(luteinizing hormone)and urinary follicular generating hormone(FSH)in girls with precocious puberty were higher than those without precocious puberty(P<0.05).The critical values of urinary luteinizing hormone and urinary follicular generative hormone in girls were 5.67 U/mmol and 1.60 U/mmol.The sensitivity of urinary luteinizing hormone(luteinizing hormone)and urinary follicular generating hormone(FOLLICle generating hormone)alone and

关 键 词：尿促性腺激素 尿卵泡生成素 尿促黄体生成素 女童性发育 GnRH激发试验 筛查方法 

分 类 号：R725.8[医药卫生—儿科]