Cellular tropism and antigenicity of mink-derived SARS-CoV-2 variants  

作　　者：Li Zhang Qianqian Li Jianhui Nie Ruxia Ding Haixin Wang Jiajing Wu Xuguang Li Xiaoming Yang Weijin Huang Youchun Wang 

机构地区：[1]Division of HIV/AIDS and Sex-transmitted Virus Vaccines,Institute for Biological Product Control,National Institutes for Food and Drug Control(NIFDC)and WHO Collaborating Center for Standardization and Evaluation of Biologicals,Beijing,China [2]Centre for Biologies Evaluation,Biologic and Radiopharmaceutical Drugs Directorate,HPFB,Health Canada,Ottawa,ON,Canada [3]China National Biotec Group Company Limited,Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第6期1668-1670,共3页信号转导与靶向治疗（英文）

基　　金：the National Natural Science Foundation of China(grant number 82073621);the Bill&Melinda Gates Foundation[Investment ID INV-006379].

摘　　要：Dear Editor,The outbreak of SARS-CoV-2 in minks has been observed recently,raising serious concerns over cross-species transmission and the emergence of variants capable of rendering antibody therapy and vaccines less effective.Here,the species tropism and antigenicity of the spike protein of ten variants were analyzed in pseudovirus-based assays involving 25 cell lines as well as 293T cells expressing ACE2 receptor from 14 species.

关 键 词：ACE2 MINK VARIANTS 

分 类 号：R373[医药卫生—病原生物学]