Ceftazidime is a potential drug to inhibit SARS-CoV-2 infection in vitro by blocking spike protein-ACE2 interaction  

作　　者：ChangDong Lin Yue Li YueBin Zhang ZhaoYuan Liu Xia Mu Chenjian Gu Jing Liu Yutang Lr GuoHui Li JianFeng Chen 

机构地区：[1]State Key Laboratory of Cell Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai,China [2]State Key Laboratory of Molecular Reaction Dynamics,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,China [3]Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS),Department of Medical Microbiology and Parasitology,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai,China [4]BSL-3 laboratory of Fudan University,School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai,China [5]School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第6期1671-1674,共4页信号转导与靶向治疗（英文）

基　　金：grants from National Key Research and Development Program of China(2020YFA0509102);National Natural Science Foundation of China(32030024,31830112,31525016 to J.F.C.,31970702,31701219 to C.D.L.);Program of Shanghai Academic Research Leader(19XD1404200);Personalized Medicines-Molecular Signature-based Drug Discovery and Development,the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12010101);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020266);the Young Elite Scientist Sponsorship Program by CAST(2019QNRC001);National Ten Thousand Talents Program.

摘　　要：Dear Editor,Coronavirus disease 2019(COVID-19)has spread globally as a severe pandemic,which is caused by a novel coronavirus named Severe Acute Respiratory Syndrome coronavirus 2(SARS-CoV-2).1 COVID-19 is a serious threat to healthcare systems,economies,and is devastating to some populations,such as the elderly and those with comorbidities.It is likely to coexist with human beings for a long time.Unfortunately,there is still no effective cure for COVID-19,especially the critically ill patients.

关 键 词：ACE2 Acute LIKELY 

分 类 号：R373[医药卫生—病原生物学]