肾移植术后JC病毒感染的最新进展  

The latest progress on JC virus infection after renal transplantation

作　　者：贺裕 欧志宇 苗芸[1] He Yu;Ou Zhiyu;Miao Yun(Department of Organ Transplantation,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院器官移植科,广州510515 [2]南方医科大学第一临床医学院

出　　处：《器官移植》2021年第4期484-488,共5页Organ Transplantation

基　　金：国家自然科学基金(8207032973);广东省自然科学基金(2020A1515010674);广州市科技计划项目(201803010109);南方医院院长基金(2018B009、2018C003);大学生创新创业训练计划项目(202012121046、X202012121239)。

摘　　要：JC病毒(JCV)是多瘤病毒家族的成员之一,在人群中的感染率约为70%,初次感染后常潜伏存在。在免疫抑制的个体中,特别是细胞免疫功能低下的情况下,JCV可以重新激活并导致严重的临床表现。近年来,JCV与肾移植术后并发症的相关性逐渐被重视,已有JCV相关性肾病(JCVAN)的报道。现就JCV的流行病学、分子生物学、体内感染过程,JCV与肾移植术后并发症以及JCV与BKV的相互关系进行综述,以期为肾移植术后免疫抑制方案的调整提供参考。JC virus(JCV)is a member of polyomaviridae family that infects approximately 70%of the population worldwide.JCV constantly stays in a latent state after the primary infection.In immunosuppressed individuals,especially under the circumstances of low cellular immune function,JCV may be reactivated and lead to severe clinical manifestations.In recent years,the correlation between JCV and complications after renal transplantation has captivated widespread attention.JCV-associated nephropathy(JCVAN)has been reported.Here,latest research progresses on the epidemiology,molecular biology,in vivo infection process,JCV and complications after renal transplantation,and the relationship between JCV and BKV were reviewed,aiming to provide reference for the adjustment of immunosuppressive regimen following renal transplantation.

关 键 词：肾移植 JC病毒 BK病毒 JC病毒相关性肾病(JCVAN) BK病毒相关性肾病(BKVAN) 多瘤病毒相关性肾病(PVAN) 进行性多灶性脑白质病(PML) 

分 类 号：R617[医药卫生—外科学] R373[医药卫生—临床医学]