重组人生长激素在多囊卵巢综合征患者促排卵治疗中的临床分析  

Clinical Analysis of Recombinant Human Growth Hormone in the Treatment of Ovulation Induction in Patients with Polycystic Ovary Syndrome

作　　者：张镱严[1] 张文悫[1] 李丽华[1] ZHANG Yiyan;ZHANG Wenque;LI Lihua(Department of Gynecology,Yuxi People's Hospital,Yuxi,Yunnan Province,653100 China)

机构地区：[1]玉溪市人民医院妇科,云南玉溪653100

出　　处：《中外医疗》2021年第13期84-86,共3页China & Foreign Medical Treatment

摘　　要：目的探讨运用重组人生长激素治疗多囊卵巢综合征(PCOS)患者促排卵的临床效果。方法方便选取2019年1月—2020年5月来该院就诊,经来曲唑诱发排卵效果不理想的163例多囊卵巢综合征患者,随机分为两组,分别为对照组82例,观察组81例。对照组用来曲唑联合重组人促卵泡激素(rhFSH)诱发排卵治疗,观察组在对照组的方案上加重组人生长激素(rhGH)。对比两组重组人促卵泡激素(rhFSH)用量及使用时间、扳机日的雌激素水平、≥14 mm的卵泡数、子宫内膜厚度及临床妊娠率情况。结果观察组的rhFSH用量使用时间均小于对照组,差异有统计学意义(t=4.490、3.442,P<0.05);观察组的HCG日子宫内膜厚度显著大于对照组,差异有统计学意义(t=4.360,P<0.05);两组HCG日≥14 mm卵泡数、雌激素水平差异无统计学意义(t=0.928、0.060,P>0.05);观察组的临床妊娠率为30.86%(25/81),对照组为30.48%(25/82),两组患者的临床妊娠率差异无统计学意义(χ^(2)=0.003,P>0.05)。结论PCOS患者诱发排卵周期中给予rhGH治疗可以减少rhFSH用量、缩短rhFSH使用时间,增加子宫内膜厚度,对临床妊娠率无明显改变。Objective To investigate the clinical effect of using recombinant human growth hormone to treat patients with polycystic ovary syndrome(PCOS)for ovulation induction.Methods Conveniently selected 163 patients with polycystic ovary syndrome who came to the hospital from January 2019 to May 2020,the effect of letrozole inducing ovulation was not satisfactory.They were randomly divided into two groups,82 cases in the control group,81 cases in the observation group.The control group was used to induce ovulation therapy with trazole combined with recombinant human follicle stimulating hormone(rhFSH),and the observation group was added with recombinant human growth hormone(rhGH)to the control group's protocol.The two groups of recombinant human follicle-stimulating hormone(rhFSH)dosage and use time,estrogen level on the trigger day,number of follicles≥14 mm,endometrial thickness,and clinical pregnancy rate were compared between the two groups.Results The dosage and use time of rhFSH in the observation group were less than those in the control group,and the difference was statistically significant(t=4.490,3.442,P<0.05);the HCG-day endometrial thickness of the observation group was significantly greater than that of the control group,and the difference was statistically significant(t=4.360,P<0.05);There was no statistically significant difference in the number of follicles and estrogen levels between the two groups on HCG days≥14 mm(t=0.928,0.060,P>0.05);the clinical pregnancy rate of the observation group was 30.86%(25/81),the control group was 30.48%(25/82),there was no statistically significant difference in the clinical pregnancy rate between the two groups(χ^(2)=0.003,P>0.05).Conclusion RhGH treatment during the ovulation induction cycle of PCOS patients can reduce the dosage of rhFSH,shorten the use time of rhFSH,increase the thickness of the endometrium,and have no significant change in the clinical pregnancy rate.

关 键 词：多囊卵巢综合征 重组人生长激素 临床效果 

分 类 号：R711[医药卫生—妇产科学]