2019年中国麻疹风疹实验室网络运转状况  

Running status of the China Measles and Rubella Laboratory Network in 2019

作　　者：宋金华[1] 郭晋源 王慧玲[1] 朱贞[1] 毛乃颖[1] 崔爱利[1] 曹蕾[1] 许文波[1,2] 张燕[1,2] Song Jinhua;Guo Jinyuan;Wang Huiling;Zhu Zhen;Mao Naiying;Cui Aili;Cao Lei;Xu Wenbo;Zhang Yan(NHC Key Laboratory of Medical Virology and Viral Diseases/National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention/WHO WPRO Regional Reference Measles and Rubella Laboratory,Beijing 102206,China;Center for Biosafety Mega-science,Chinese Academy of Sciences,Wuhan 430000,Hubei,China)

机构地区：[1]国家卫生健康委员会医学病毒和病毒病重点实验室/中国疾病预防控制中心病毒病预防控制所/世界卫生组织西太平洋地区麻疹风疹参比实验室,北京102206 [2]中国科学院生物安全大科学研究中心,湖北武汉430000

出　　处：《中国疫苗和免疫》2021年第3期246-249,共4页Chinese Journal of Vaccines and Immunization

基　　金：十三五国家科技重大专项课题(2018ZX10201-002-006、2018ZX10711001、2018ZX10713002、2018ZX10713001003)。

摘　　要：目的评价2019年中国麻疹风疹实验室网络(China Measles and Rubella Laboratory Network,CMRLN)运转状况。方法利用中国麻疹监测信息报告管理系统(Measles Surveillance System,MSS)和CMRLN实验室监测数据库,分析CMRLN运转指标和麻疹风疹病例实验室监测结果。结果2019年全国报告监测病例78787例,其中散发病例65507例,散发病例的血标本、病原学标本采集率分别为95.86%、50.16%,3d内送达网络实验室的比例分别为97.89%、84.13%。监测病例的麻疹、风疹病毒IgM检测阳性率分别为4.65%(3226/69436)、31.14%(21784/69963)。散发监测病例麻疹、风疹病毒核酸检测阳性率分别为3.28%(1090/33254)、31.31%(10367/33112)。全国报告麻疹、风疹暴发疫情分别为24起、177起,实验室确诊率分别为100%、99.44%。共分离到265株麻疹病毒,其中D8、A(疫苗相似株)、B3和H1基因型分别为176株、18株、51株和30株;分离到风疹病毒2822株,其中1E和2B基因型分别为1608株和1214株。国家、32个省级、27个地市级网络实验室均通过了麻疹和风疹血清盲样、核酸盲样和/或基因定型考核。结论2019年中国麻疹风疹实验室网络运转良好,为中国麻疹和风疹的消除提供了技术支撑。Objective To evaluate the running status of the China Measles and Rubella Laboratory Network(CMRLN)in 2019.Methods We obtained data from the Measles Surveillance System(MSS)and CMRLN to analyze the performance indicators for CMRLN and assess laboratory data on measles and rubella cases.Results A total of 78787 surveillance(suspected)cases were reported in 2019 in China,of which 65507 were sporadic cases.Blood and pathogenic samples were collected from 95.86%and 50.16%of sporadic cases,respectively,with 97.89%and 84.13%of samples delivered to network laboratories within 3 days.Positivity rates of measles and rubella IgM antibodies in surveillance cases were 4.65%(3226/69436)and 31.14%(21784/69963),respectively.Positivity rates of measles and rubella nucleic acids in sporadic cases were 3.28%(1090/33254)and 31.31%(10367/33112).A total of 24 measles outbreaks and 177 rubella outbreaks were reported,of which 100%and 99.44%were lab-confirmed.There were 265 measles virus isolates,among which 176,18,51,and 30 were identified as genotype D8,A(vaccine strain),B3,and H1,respectively.There were 2822 rubella virus isolates,among which 1608 were genotype 1 E and 1214 were genotype 2 B.The national,32 provincial,and 27 prefectural network laboratories passed serum,nucleic acid,and/or genotyping blind-sample examinations of measles and rubella.Conclusions The CMRLN ran well in 2019;it provided technological support for the elimination of measles and rubella in China.

关 键 词：麻疹风疹实验室网络 病毒学监测 质量控制 

分 类 号：R373.1[医药卫生—病原生物学]