初发多囊卵巢综合征合并糖耐量减低患者临床干预前后性激素及糖脂代谢指标变化情况分析  

Analysis of changes of sex hormone and glucolipid metabolism indexes in patients with initial polycystic ovary syndrome complicated with impaired glucose tolerance before and after clinical intervention

作　　者：杨茜[1] 张俊飞[1] 牛帅 马静静[2] 周雪[2] 李志红[2] YANG Qian;ZHANG Junfei;NIU Shuai;MA Jingjing;ZHOU Xue;LI Zhihong(Department of Nutrition,the First Central Hospital of Baoding,Baoding,Hebei 071000,China;Department of Endocrinology,the First Central Hospital of Baoding,Baoding,Hebei 071000,China)

机构地区：[1]保定市第一中心医院营养科,河北保定071000 [2]保定市第一中心医院内分泌二科,河北保定071000

出　　处：《国际检验医学杂志》2021年第13期1580-1583,共4页International Journal of Laboratory Medicine

摘　　要：目的分析初发多囊卵巢综合征(PCOS)合并糖耐量减低(IGT)患者临床干预前后血清性激素及糖脂代谢指标变化情况。方法选取2018年2月至2020年2月于该院就诊的初发PCOS合并IGT患者100例作为研究组,初发PCOS不合并IGT患者50例作为疾病对照组,另选取同期于该院体检健康者50例作为健康对照组。研究组患者采用个体化饮食干预及口服盐酸二甲双胍片等治疗。比较3组及研究组干预前后性激素及糖脂代谢指标卵泡生成素(FSH)、雌激素(E2)、促黄体生成素(LH)、睾酮(T)水平及空腹血糖(FPG)、空腹胰岛素(FIN)、三酰甘油(TC)、总胆固醇(TG)水平。结果研究组血清FSH、LH、T水平及FPG、FIN、TC、TG水平显著高于疾病对照组和健康对照组,血清E2水平显著低于疾病对照组和健康对照组,差异均有统计学意义(P<0.05);疾病对照组血清FSH、LH、T水平显著高于健康对照组,血清E2水平显著低于健康对照组,差异均有统计学意义(P<0.05),疾病对照组血清FPG、FIN、TC、TG水平与健康对照组比较,差异无统计学意义(P>0.05);研究组患者干预后血清FSH、LH、T水平及FPG、FIN、TC、TG水平显著低于干预前,血清E2水平显著高于干预前,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,TG、FPG、FIN是初发PCOS合并IGT的危险因素(OR=2.957、2.278、2.759,P<0.05)。结论初发PCOS合并IGT患者治疗前性激素、糖脂代谢均有异常,干预治疗后血清FSH、LH、T水平及FPG、FIN、TC、TG水平显著降低,血清E2水平显著升高,提示调节性激素水平、改善糖脂代谢可能在初发PCOS合并IGT患者的病情改善中发挥积极作用。Objective To analyse the changes of sex hormone and glucolipid metabolism indexes in patients with initial polycystic ovary syndrome(PCOS)complicated with impaired glucose tolerance(IGT)before and after clinical intervention.Methods A total of 100 cases of newly diagnosed PCOS patients with IGT admitted to this hospital from February 2018 to February 2020 were selected as the study group,50 cases of newly diagnosed PCOS patients without IGT were selected as the control group,and 50 cases of healthy subjects who underwent physical examination in this hospital during the same period were selected as the healthy control group.Patients in the study group received individulized dietary interventions and oral metformin hydrochloride tablets.The levels of sex hormones and glucolipid metabolismindexes,including follicle generation hormone(FSH),estrogen(E2),luteinizing hormone(LH),testosterone(T),fasting blood glucose(FPG),fasting insulin(FIN),triacylglycerol(TC)and total cholesterol(TG),were compared between the three groups and the study group before and after intervention.Results The serum levels of FSH,LH,T,FPG,FIN,TC and TG in the study group were significantly higher than those in the disease control group and healthy control group,and the serum E2 level was significantly lower than that in the disease control group and healthy control group,the differences were statistically significant(P<0.05).The serum levels of FSH,LH and T in the disease control group were significantly higher than those in the healthy control group,and the serum levels of E2 were significantly lower than those in the healthy control group,with statistical significance(P<0.05).The serum levels of FPG,FIN,TC and TG in the disease control group were not significantly different from those in the healthy control group(P>0.05).After intervention,the serum levels of FSH,LH,T,FPG,FIN,TC and TG in the study group were significantly lower than before intervention,and the serum E2 level was significantly higher than before intervention,with statistical s

关 键 词：初发多囊卵巢综合征 糖耐量 性激素 糖脂代谢 

分 类 号：R711.75[医药卫生—妇产科学] R587.1[医药卫生—临床医学]