哮喘-慢阻肺重叠、哮喘和慢性阻塞性肺疾病患者诱导痰VEGF、ICAM-1、IL-13、呼出气一氧化氮水平的变化及临床意义  

VEGF,ICAM-1,IL-13,FeNO level of induced sputum on asthma,asthma-copd overlap,and chronic obstructive pulmonary disease in patients:clinical changes and significance

作　　者：付群[1] 郭迪[1] 赵文飞[1] Fu Qun;Guo Di;Zhao Wenfei(Department of Respiratory and Critical Care, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China)

机构地区：[1]郑州大学第五附属医院呼吸与危重症医学科,河南郑州450052

出　　处：《临床荟萃》2021年第6期513-516,共4页Clinical Focus

摘　　要：目的探讨哮喘-慢阻肺重叠(ACO)、哮喘、慢性阻塞性肺疾病(COPD)患者诱导痰血管内皮生长因子(VEGF)、细胞间黏附分子-1(ICAM-1)、白介素-13(IL-13)、呼出气一氧化痰(FeNO)水平的变化及临床应用价值。方法选取2018年6月~2020年6月在我院治疗的哮喘患者77例(哮喘组)、COPD患者78例(COPD组),ACO患者80例(ACO组),对比3组一般资料、肺功能指标及VEGF、ICAM-1、IL-13、FeNO水平。结果COPD组年龄高于ACO组,ACO组年龄高于哮喘组(P<0.05);哮喘组有吸烟史比例患者高于ACO组,ACO组有吸烟史患者比例高于COPD组(P<0.05);ACO组、哮喘组有家族史患者比例高于COPD组(均P<0.05);ACO组、COPD组FEV1、FEV1/FVC、FEV1/pre%低于哮喘组,而小气道功能障碍发生率、RV/TLC高于哮喘组(均P<0.05);ACO组与COPD组上述指标差异无统计学意义(均P>0.05);ACO组、哮喘组VEGF、ICAM-1高于COPD组,ACO组VEGF高于哮喘组(均P<0.05);哮喘组IL-13、FeNO高于ACO组及COPD组,ACO组FeNO高于COPD组(均P<0.05)。结论ACO、哮喘、COPD患者VEGF、ICAM-1、IL-13、FeNO水平存在明显差异,对于临床诊治具有一定的参考价值。Objective To investigate clinical changes and value of vascular endothelial growth factor(VEGF),intercellular adhesion molecule-1(ICAM-1),interleukin-13(IL-13),fractionated exhaled nitric oxide(FeNO)level of induced sputum on asthma,asthma-copd overlap syndrome(ACO),and chronic obstructive pulmonary disease(COPD)in patients.Methods Totally 77 asthma patients(asthma group),78 COPD patients(COPD group)and 80 ACO patients(ACO group)were selected in our hospital from Jun 2018 to Jun 2020,general data,lung function indicators and levels of VEGF,ICAM-1,IL-13,FeNO were obtained among the three groups.Results Among the three groups,age in COPD group was the oldest,in descending order:COPD group>ACO group>asthma group(allP<0.05);smoking history in ACO group was highest,in descending order:asthma group>ACO group>COPD group(P<0.05);proportion of patients with family history of smoking in asthma group and ACO group were increased generally(all P<0.05).FEV1,FEV1/FVC,FEV1/pre%in ACO group and COPD group were significantly lower than those in asthma group,but incidence of small airway dysfunction,RV/TLC were higher than those in asthma group(P<0.05);there were no statistically significant differences in above indicators between ACO group and COPD group(all P>0.05).VEGF and ICAM-1 in ACO group,asthma group were higher than those in COPD group,VEGF in ACO group was higher than that in asthma group(P<0.05).IL-13,FeNO in asthma group were hither than those in ACO group and COPD group,FeNO in ACO group was higher than that in COPD group(all P<0.05).Conclusion Levels of VEGF,ICAM-1,IL-13,FeNO are significantly different among asthma,ACO and COPD in patients,which has certain reference for clinic.

关 键 词：哮喘 肺疾病 慢性阻塞性 炎症因子 肺功能 诊断 生化指标 

分 类 号：R562.25[医药卫生—呼吸系统] R563.9[医药卫生—内科学]