Functionalization of PEG-PM PC-based polymers for potential theranostic applications  

作　　者：Ning CHEN Sidi LI Xueping LI Lixia LONG Xubo YUAN Xin HOU Jin ZHAO 

机构地区：[1]Tianjin Key Laboratory of Composite and Functional Materials,Tianjin 300350,China [2]School of Materials Science and Engineering,Tianjin University,Tianjin 300350,China

出　　处：《Frontiers of Materials Science》2021年第2期280-290,共11页材料学前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.51673146,51673144 and 51773151).

摘　　要：The synergistic effect of polyethylene glycol(PEG)and poly(2-methacry-loyloxyethyl phosphorytcholine)(PMPC)can effectively reduce the protein absorption,which is beneficial to theranostics.However,PEG-PMPC-based polymers have rarely been used as nanocarriers in the theranostic field due to their limited modifiability and weak interaction with other materials.Herein,a plain method was proposed to endow them with the probable ability of loading small active agents,and the relationship between the structure and the ability of loading hydrophobic agents was explored,thus expanding their applications.Firstly,mPEG-PMPC or 4-arm-PEG-PMPC polymer was synthesized by atom transfer radical polymerization(ATRP)using mPEG-Br or 4-arm-PEG-Br as the macroinitiator.Then a strong hydrophobic segment,poly(butyl methacrylate)(PBMA),was introduced and the ability to load small hydrophobic agents was further explored.The results showed that linear mPEG-PMPC-PBMA could form micelles 50-80 nm in size and load the hydrophobic agent such as Nile red efficiently.In contrast,star-like 4-arm-PEG-PMPC-PBiyiA,a monomolecular micelle(10-20 nm),could hardly load any hydrophobic agent.This work highlights effective strategies for engineering PEG-PMPC-based polymers and may facilitate the further application in numerous fields.

关 键 词：polyethylene glycol poly(2-methacryloyloxyethyl phosphorylcholine) atom transfer radical polymerization self-assembly monomolecular micelles 

分 类 号：O63[理学—高分子化学]