系统性红斑狼疮患者血小板参数、血脂、补体C3、C4水平与病情活动度的关系分析  

Analysis of the Relationship between Platelet Parameters,Blood Lipid,Levels of Complement C3 and C4 and Disease Activity in Patients with Systemic Lupus Erythematosus

作　　者：董海芸[1] 宋维兴 李玉川[1] 韩芳 孙雪 DONG Hai-yun;SONG Wei-xing;LI Yu-chuan;HAN Fang;SUN Xue(Department of Nephrology,Qinghai University Affiliated Hospital,Xining,Qinghai,810001,China)

机构地区：[1]青海大学附属医院肾病内科,青海西宁810001

出　　处：《现代生物医学进展》2021年第12期2382-2385,2400,共5页Progress in Modern Biomedicine

基　　金：青海省自然科学基金项目(2013Z0198);青海大学附属医院中青年基金项目(ASRF-2018-YB-19)。

摘　　要：目的:研究系统性红斑狼疮(SLE)患者血小板参数、血脂、补体C3、C4水平与病情活动度的关系。方法:将从2011年1月~2018年1月我院收治的100例SLE患者纳入研究,将其按照SEL疾病活动指数(SLEDAI)评分的不同分成活动组(SLEDAI评分≥10分)36例,非活动组(SLEDAI评分<10分)64例,另取同期于我院进行体检的健康志愿者100例作为对照组。比较三组各项血小板参数、血脂指标以及补体C3、C4水平,采用Pearson相关性分析SLE患者SLEDAI评分与各项指标的相关性。结果:活动组、非活动组血小板计数(PLT)、血小板压积、大血小板百分率低于对照组,且活动组PLT、大血小板百分率低于非活动组(P<0.05)。活动组、非活动组血小板平均容积(MPV)、血小板体积分布宽度(PDW)高于对照组,且活动组高于非活动组(P<0.05)。活动组、非活动组低密度脂蛋白胆固醇(LDL-C)均高于对照组,高密度脂蛋白胆固醇(HDL-C)均低于对照组(P<0.05),活动组HDL-C低于非活动组(P<0.05)。活动组、非活动组补体C3、C4水平均低于对照组,且活动组补体C3、C4水平均低于非活动组(P<0.05)。经Pearson相关性分析发现:SLE患者SLEDAI评分与PLT、大血小板百分率、HDL-C以及补体C3、C4水平呈负相关,与MPV、PDW呈正相关(P<0.05)。结论:SLE患者血小板参数PLT、大血小板百分率、血脂指标HDL-C以及补体C3、C4水平与SLEDAI评分密切相关,可能作为SLE患者疾病活动性的评估指标。Objective:To study the relationship between platelet parameters,blood lipid,levels of complement C3 and C4 and disease activity in patients with systemic lupus erythematosus(SLE).Methods:100 patients with SLE who were admitted to our hospital from January 2011 to January 2018 were included in the study,and patients were divided into the active group(SLEDAI score≥10 scores)with 36 cases and the inactive group(SLEDAI score<10 scores)with 64 cases according to the differences of SEL disease activity index(SLEDAI)score.Another 100 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the control group.Platelet parameters,blood lipid indexes and levels of complement C3 and C4 were compared among the three groups.Pearson correlation was used to analyze the correlation between SLEDAI score and various indexes in patients with SLE.Results:The platelet count(PLT),platelet deposition,large platelets percentage in the active group and the inactive group were lower than those in the control group,PLT and large platelets percentage in the active group were lower than those in the inactive group(P<0.05).Mean platelet volume(MPV)and platelet volume distribution width(PDW)in the active group and the inactive group were higher than those in the control group,and the active group was higher than that in the inactive group(P<0.05).Low density lipoprotein cholesterol(LDL-C)in the active group and the inactive group were higher than that in the control group,high density lipoprotein cholesterol(HDL-C)was lower than that in the control group(P<0.05),and HDL-C in the active group was lower than that in the inactive group(P<0.05).The levels of complement C3 and C4 in the active group and the inactive group were lower than those in the control group,and the levels of complement C3 and C4 in the active group were lower than those in the inactive group(P<0.05).Pearson correlation analysis showed that SLEDAI score in patients with SLE were negatively correlated with PLT,large platelet perc

关 键 词：系统性红斑狼疮 疾病活动度 血小板参数 补体 血脂 

分 类 号：R593.24[医药卫生—内科学]