HAP-TCP复合生物陶瓷浆料的激光3D打印及性能研究  

Laser 3D Printing and Properties of HAP-TCP Composite Bioceramic Materials

作　　者：王志勇 蔡志祥 刘国承[2] 孙智龙 张铁 WANG Zhiyong;CAI Zhixiang;LIU Guocheng;SUN Zhilong;ZHANG Tie(Wuhan Intelligent Laser Technology Co.LTD,Wuhan 430000,China;Hubei Key Laboratory of Advanced Technology for Automotive Components,Wuhan University of Technology,Wuhan 430070,China;Hubei Lianjie Biological Materials Co.LTD,Wuhan 430000,China)

机构地区：[1]武汉因泰莱激光科技有限公司,武汉430000 [2]武汉理工大学,现代汽车零部件技术湖北省重点实验室,武汉430070 [3]湖北联结生物材料有限公司,武汉430000

出　　处：《材料导报》2021年第S01期104-107,131,共5页Materials Reports

基　　金：国家重点研发项目(2018YFB1106700)。

摘　　要：羟基磷灰石(HAP)和磷酸三钙(TCP)是临床上常用的骨修复支架材料,将两者复合可以得到成型精度高、成骨性好、降解速度快的复合材料。本工作采用激光3D打印机打印,可以满足不规则人工骨的成型要求。将HAP-TCP复合陶瓷粉体与丙烯酸酯单体及其他助剂混合后进行球磨,得到陶瓷浆料。通过对打印工艺的研究确定了最佳固化深度为分层厚度的3~4倍,最佳扫描速度为2000 mm/s,并通过TG-DSC曲线的分析,得到生坯的烧结温度范围,通过对几种烧结温度的测试,确定了最佳烧结温度为1000℃。最后在最佳工艺参数下打印支架,通过SEM的观察可知晶相结合紧密,最后通过动物实验可知,支架植入老鼠颅骨后,大鼠未见死亡及不良反应症状,且能看到有成骨现象。Hydroxyapatite(HAP)and tricalcium phosphate(TCP)are scaffold materials that are widely used in bone repair.The composite materials of HAP and TCP can obtain high molding accuracy,good osteogenesis and fast degradation.A SLA-system was used in this study to print green part,this system can meet the requirements of irregular artificial bone formation.The HAP-TCP composite ceramic powders were mixed with an acrylic resin and other additives,then ball-milling was performed to obtain a ceramic slurry.Through the study of printing process,the optimal curing depth is determined to be 3—4 times of the layer thickness and the optimal scanning speed is 2000 mm/s.The sintering temperature range of the green part was obtained through the analysis of the TG-DSC curve.By testing several sintering temperatures,we confirmed that the optimal sintering temperature was 1000℃.Finally,under the best process parameters,we printed the ceramic scaffold.Through the SEM observation,we could see the tightly combined crystals.Finally,animal experiments showed that after the scaffold was implanted in the skull of the mouse.And we did not see any symptoms of death and adverse reactions of the mouse,and we also saw the osteogenesis phenomenon.

关 键 词：激光3D打印 复合生物陶瓷 打印工艺 动物实验 

分 类 号：TB39[一般工业技术—材料科学与工程]