组织细胞坏死性淋巴结炎^(18)F-FDG PET/CT表现  

^(18)F-FDG PET/CT findings of histiocytic necrotizing lymphadenitis

作　　者：郭娜 张燕燕[1] GUO Na;ZHANG Yanyan(Department of Nuclear Medicine,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院核医学科,北京100191

出　　处：《中国医学影像技术》2021年第6期862-866,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的观察组织细胞坏死性淋巴结炎(HNL)^(18)F-FDG PET/CT表现。方法回顾性分析11例经病理证实HNL患者的^(18)F-FDG PET/CT及临床表现,分区域选取^(18)F-FDG摄取最高的病变淋巴结54枚,分析其最大径、位置与最大标准摄取值(SUV_(max))的相关性。结果11例HNL中,7例受累淋巴结呈全身性分布,4例仅颈部和/或腋窝淋巴结受累;11例颈部淋巴结均受累,9例腋窝淋巴结受累;受累淋巴结呈卵圆形,最大短径均<2.30 cm,密度多均匀,且无融合趋势;^(18)F-FDG PET/CT显像见不同程度放射性摄取,SUV_(max)为1.22~23.34,中位SUV_(max)为5.56(2.37,9.87)。8例发热患者中,6例中轴骨摄取高于肝脏。淋巴结最大短径、最大长径均与SUV_(max)呈低度正相关(r=0.496,P<0.001;r=0.347,P=0.010),所在位置与SUV_(max)无明显相关(r=0.019,P=0.892)。结论HNL于^(18)F-FDG PET/CT显像主要表现为全身多发淋巴结轻、中度肿大,颈部及腋窝淋巴结多受累及代谢增高,伴或不伴中轴骨代谢增高。^(18)F-FDG PET/CT可用于评估HNL患者全身淋巴结受累、判断疾病活动度及辅助活检定位。Objective To observe the^(18)F-FDG PET/CT manifestations of histiocytic necrotizing lymphadenitis(HNL).Methods^(18)F-FDG PET/CT imaging and clinical manifestations of 11 patients with HNL confirmed by pathology were retrospectively analyzed.Fifty-four lymph nodes with the highest^(18)F-FDG uptakes were selected from different aeras,and the correlations of the maximum diameter,location and maximum standard uptake value(SUV_(max))were analyzed.Results The involved lymph nodes distributed in the whole body in 7 patients,while the lesions only involved lymph nodes in the neck and/or axillary.Involved lymph nodes in the neck were detected in all 11 cases,while in the axillary in 9 cases.The involved lymph nodes were oval-shaped,with the maximum short diameter less than 2.30 cm and uniform density,without trend of fusion.^(18)F-FDG PET/CT imaging showed different degrees of radioactive uptake,SUV_(max)ranged from 1.22 to23.34,and the median SUV_(max)was 5.56(2.37,9.87).In 8 patients with fever,axial bone uptake was higher than that of liver in 6 patients.The maximum short diameter and the maximum long diameter of lymph nodes were positively low correlated with SUV_(max)(r=0.496,P<0.001;r=0.347,P=0.010).There was no correlation of SUV_(max)and location(r=0.019,P=0.892).Conclusion HNL mainly manifested as multiple mild to moderate lymph nodes enlargement distributed in the whole body,esp.neck and axillary lymph nodes involvement with increased metabolism,accompanied with increased axial bone metabolism or not on^(18)F-FDG PET/CT imaging.^(18)F-FDG PET/CT could be used to evaluate systemic lymph node involvement,assess the activity of lesions and guiding biopsy.

关 键 词：组织细胞性坏死性淋巴结炎 正电子发射断层显像 体层摄影术 X线计算机 18F氟脱氧葡萄糖 

分 类 号：R59[医药卫生—内科学] R817.4[医药卫生—临床医学]