血液灌流辅助常规治疗重症急性有机磷农药中毒的效果  

Effects of blood perfusion in adjuvant treatment of severe acute organophosphorus pesticide poisoning

作　　者：孙丽薇 SUN Liwei(Intensive Care Unit of the Central Hospital of Jiamusi City,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市中心医院重症科,黑龙江佳木斯154002

出　　处：《中国民康医学》2021年第10期8-10,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察血液灌流辅助常规治疗对重症急性有机磷农药中毒(SAOPP)患者的效果。方法:选取50例SAOPP患者为研究对象,按随机数字表法分为对照组和研究组各25例。对照组采用盐酸戊乙奎醚、阿托品、氯解磷定等常规药物治疗,研究组在对照组基础上联合血液灌流治疗,比较两组临床疗效、症状改善时间、住院时间、不良事件发生率及病死率。结果:研究组治疗总有效率为96.67%(29/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);研究组阿托品化时间、胆碱酯酶活力恢复时间、中毒症状消失时间、住院时间均短于对照组,差异有统计学意义(P<0.05);两组不良事件发生率、病死率比较,差异均无统计学意义(P>0.05)。结论:血液灌流辅助常规药物治疗SAOPP患者效果确切,能够缩短阿托品化时间,促进患者中毒症状消失及胆碱酯酶活力恢复,安全性较好。Objective:To investigate effects of blood perfusion in adjuvant treatment of severe acute organophosphorus pesticide poisoning(SAOPP).Methods:50 SAOPP patients were selected and divided into control group and study group according to the random number table method,each with 25 cases.The control group was treated with Penehyclidine hydrochloride,Atropine,Pralidoxime chloride and other conventional drugs,while the study group was combined with blood perfusion on the basis of those of the control group.The clinical efficacy,the symptom improvement time,the hospitalization time,the incidence of adverse events and the mortality rate were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.67%(29/30),which was higher than 73.33%(22/30)in the control group,and the difference was statistically significant(P<0.05).The atropinization time,cholinesterase activity recovery time,disappearance time of poisoning symptoms,and hospitalization time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).However,there were no statistically significant differences in the incidence of adverse events and the rate mortality between the two groups(P>0.05).Conclusions:Blood perfusion in the adjuvant treatment of the SAOPP patients undergoing the conventional treatment has definite effects.Moreover,it can shorten the atropinization time and promote the disappearance of the poisoning symptoms and the recovery of cholinesterase activity with good safety.

关 键 词：重症急性有机磷农药中毒 血液灌流 盐酸戊乙奎醚 阿托品 

分 类 号：R595.4[医药卫生—内科学]