酸催化制备β环香叶基苯基砜  

Acid-catalyzed Preparationofβ-ring Geranyl Phenyl Sulfone

作　　者：莫谷妹 MO Gu-mei(Guangzhou Juyuan Biochemical Limited Company,Guangdong Guangzhou 510663,China)

机构地区：[1]广州巨元生化有限公司,广东广州510663

出　　处：《广州化工》2021年第13期47-49,共3页GuangZhou Chemical Industry

摘　　要：β环香叶基苯基砜是制备维生素A、β胡萝卜素的重要中间体,在化工、制药、化妆品等领域有着广泛的应用,其合成途径主要是由香叶基苯基砜经环合反应得到。本文深入研究了在硫酸或对甲苯磺酸催化条件下,不同的酸浓度、用量、温度等因素对反应的影响,发现硫酸比对甲苯磺酸效果好,得到其最佳实验条件,最终成功制备得到纯度为96%以上的β环香叶基苯基砜纯品。β-ring geranyl phenyl sulfone is an important intermediate for the preparation of vitamin A andβ-carotene.It has a wide range of applications in the chemical,pharmaceutical,cosmetic and other fields.Its synthesis route is mainly obtained by cyclization reaction of geranyl phenyl sulfone.The effect of different acid concentration,dosage,temperature and other factors on the reaction under the conditions of sulfuric acid or p-toluenesulfonic acidwas studied,it wasfound that sulfuric acid was more effective than p-toluenesulfonic acid.The best experimental conditions were obtained and the preparation was finally successful.A pure product ofβ-ring geranyl phenyl sulfone with a purity of more than 96%was obtained.

关 键 词：香叶基苯基砜 环合 β环香叶基苯基砜 

分 类 号：TQ247[化学工程—有机化工]