平肝脉通片治疗阴虚阳亢型高血压患者的疗效观察  

Observation on Therapeutic Effect of Pinggan Maitong Tabletin Treating Hypertension with Yin Deficiency and Yang Hyperactivity

作　　者：渠乐[1] 周云[2] 沈宝藩 QU Le;ZHOU Yun;SHEN Bao-fan(Department of Cardiology,Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University,Urumqi Xinjiang 830000;ShenBaofan Master of Traditional Chinese Medicine Studio,Urumqi Xinjiang 830000)

机构地区：[1]新疆医科大学附属中医医院干一科,新疆乌鲁木齐830000 [2]新疆医科大学附属中医医院心内四科,新疆乌鲁木齐830000 [3]沈宝藩国医大师工作室,新疆乌鲁木齐830000

出　　处：《世界中西医结合杂志》2021年第6期1098-1102,1107,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：新疆医科大学附属中医医院院级课题项目(ZYY201705)。

摘　　要：目的观察平肝脉通片治疗阴虚阳亢型高血压患者的疗效。方法研究对象选取2017年1月—2018年12月期间在新疆医科大学附属中医医院干部科住院的阴虚阳亢高血压1~2级患者123例,随机分为对照组(60例)和观察组(63例)。对照组患者给予氨氯地平治疗,在此基础上,观察组患者加用院内制剂平肝脉通片治疗。两组患者均持续干预6个月后,比较两组患者的治疗总有效率、并发症发生率以及治疗前后血压水平、中医证候积分和血清一氧化氮(NO)、内皮素-1(ET-1)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALDO)水平。结果治疗后对照组治疗总有效率为50.00%(30/60),观察组为74.60%(47/63),观察组总有效率明显高于对照组,两组比较,差异有统计学意义(χ2=8.000,P=0.005,P<0.05)。治疗后两组患者收缩压、舒张压水平与治疗前比较均降低,差异有统计学意义(P<0.05),且观察组治疗后收缩压、舒张压水平均明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者眩晕、头痛、五心烦热、心悸失眠中医证候积分均低于治疗前(P<0.05),且观察组治疗后眩晕、头痛、五心烦热、心悸失眠中医证候积分均明显低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后两组患者血清ET-1、AngⅡ、ALDO水平均低于治疗前,NO水平高于治疗前(P<0.05),且观察组治疗后血清ET-1、AngⅡ、ALDO水平明显低于对照组,NO水平明显高于对照组,两组比较,差异有统计学意义(P<0.05)。治疗期间观察组并发症发生率为9.52%(6/63),对照组为21.67%(13/60),观察组并发症发生率明显低于对照组,两组比较,差异有统计学意义(χ2=4.183,P=0.041,P<0.05)。结论运用平肝脉通片治疗阴虚阳亢型高血压的疗效显著,能改善其中医证候,稳定降压,安全有效。Objective To study the efficacy of Pinggan Maitong Tablets in treating hypertension of Yin deficiency and Yang hyperactivity.Methods 123 patients with grade 1-2 hypertension of Yin deficiency and Yang hyperactivity,who have been hospitalized in the affiliated hospital of traditional Chinese medicine of Xinjiang medical university since January 2017 to December 2018,they were randomly divided into control group(60 cases)and observation group(63 cases).Patients in the control group were treated with amlodipine,and patients in the observation group were treated with Pinggan Maitongtablet on the basis of control group.After continuous intervention for 6 months,the total effective rate of treatment,the incidence of complications,blood pressure levels before and after treatment,TCM syndrome scores,and serum nitric oxide(NO),endothelin-1(ET-1),angiotensin II(Ang II)and plasma aldosterone(ALDO)levels.Results After treatment,the total effective rate of treatment in the control group was 50.00%(30/60),and the observation group was 74.60%(47/63).The observation group was significantly higher than the control group(χ2=8.000,P=0.005,P<0.05).After treatment,the systolic and diastolic blood pressure levels of the two groups were lower than before treatment(P<0.05),and the systolic and diastolic blood pressure levels of the observation group after treatment were significantly lower than those of the control group(P<0.05).After treatment,the scores of TCM syndromes of dizziness,headache,five upsetheat,palpitations and insomnia of the two groups were lower than before treatment(P<0.05),and the scores of TCM syndromes of dizziness,headache,five upset heat,palpitations and insomnia in the observation group after treatment were all lower Significantly lower than the control group(P<0.05).After treatment,serum ET-1,AngⅡ,ALDO levels of the two groups were lower than before treatment,and NO levels were higher than before treatment(P<0.05),and serum ET-1,AngⅡ,ALDO levels of the observation group after treatment were significantly lo

关 键 词：平肝脉通片 阴虚阳亢型 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]