胶原蛋白基纳米复合材料的性能及界面研究进展  

Progress on properties and interface of collagen-based nanocomposites

作　　者：刘晨阳 马建中 张跃宏[1,2,3] LIU Chenyang;MA Jianzhong;ZHANG Yuehong(College of Bioresources Chemical and Materials Engineering,Shaanxi University of Science&Technology,Xi’an 710021,China;National Demonstration Center for Experimental Light Chemistry Engineering Education,Shaanxi University of Science&Technology,Xi’an 710021,China;Xi’an Key Laboratory of Green Chemicals and Functional Materials,Xi’an 710021,China)

机构地区：[1]陕西科技大学轻工科学与工程学院,西安710021 [2]轻化工程国家级实验教学示范中心(陕西科技大学),西安710021 [3]西安市绿色化学品与功能材料重点实验室,西安710021

出　　处：《复合材料学报》2021年第6期1691-1702,共12页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(21838007)。

摘　　要：胶原蛋白(COL)是一种绿色可再生的有机天然高分子材料,具有优异的生物相容性、可生物降解性和低抗原性等特点,将具有独特功能特性的无机纳米材料引入其中,可以开发出兼具二者优异性能的新型COL基纳米复合材料。然而,无机纳米材料与有机COL之间的界面结合特性会显著影响所制备复合材料的性能。因而,有必要研究纳米材料与COL之间的界面结合特性。本文系统回顾了未改性/有机化改性纳米材料对COL基纳米复合材料性能影响的研究现状,重点阐述了通过现代仪器分析表征方法和分子动力学模拟两种方法对纳米材料与COL之间的界面研究进展,对比了两种方法的优缺点,展望了COL基纳米复合材料性能及界面研究未来可能的发展趋势,指出在COL中引入新型纳米材料制备绿色化、多功能化、高性能化、应用多元化的COL基纳米复合材料及利用多种现代仪器分析方法和计算机模拟相结合的手段进行界面研究是未来的主要研究方向。Collagen(COL) is a green and renewable organic natural polymer material with excellent biocompatibility, biodegradability and low antigenicity. A series of novel collagen-based nanocomposites combining excellent properties of two components could be developed by introducing inorganic nanomaterials with unique functional characteristics into collagen matrix. However, the interface interaction characteristics between inorganic nanomaterials and organic COL have a significant effect on the properties of the corresponding nanocomposites. Therefore,it is necessary to investigate the interface interaction between nanomaterials and COL. This paper systematically reviewed the main research status of the effect of unmodified/modified nanomaterials on the properties of COLbased nanocomposite, and summarized the progress of the interface research between nanomaterials and COL through methods of modern instrumental analysis and molecular dynamics simulation. Moreover, the advantages and disadvantages of the two methods were compared. Finally, the possible future research trend of the interfaceinteraction between nanomaterials and COL matrix was prospected. It is pointed out that the introduction of nanomaterials into the COL matrix to prepare environmentally friendly, multi-functional, high-performance, and widely used COL-based nanocomposites, and the combination of modern instrument analysis methods and computer simulation methods to conduct interface research will be the main research directions in the future.

关 键 词：复合材料 胶原蛋白 纳米材料 界面 分子动力学 

分 类 号：TB332[一般工业技术—材料科学与工程] TQ93[化学工程]