静电纺丝法制备多功能聚乙烯醇微球及其性能和应用  

Preparation of multifunctional polyvinyl alcohol microspheres by electrospinning and its properties and application

作　　者：王世革[1] 徐霞 陈永康 叶长青 安潇 WANG Shige;XU Xia;CHEN Yongkang;YE Changqing;AN Xiao(College of Science,University of Shanghai for Science and Technology,Shanghai 200093,China;Oncology Interventional Department,Shanghai First People’s Hospital,Shanghai 200080,China)

机构地区：[1]上海理工大学理学院,上海200093 [2]上海市第一人民医院肿瘤介入科,上海200080

出　　处：《复合材料学报》2021年第6期1960-1973,共14页Acta Materiae Compositae Sinica

基　　金：上海市青年科技启明星计划(20QA1407200);上海市浦江人才计划(18PJD040);国家自然科学基金(81972904,51702214)。

摘　　要：通过静电纺丝法,制备了MnO_(2)-聚多巴胺(PDA)/聚乙烯醇(PVA)和MnO_(2)-PDA-5-氟尿嘧啶(5-Fu)/PVA复合微球。具体地,在PVA溶液中依次加入多巴胺(DA)与KMnO_(4),在所得溶液中,DA与KMnO_(4)发生氧化还原反应,原位聚合生成PDA,而KMnO_(4)转变为MnO_(2),通过静电纺丝法制备了MnO_(2)-PDA/PVA微球。向上述溶液中加入化疗药物5-Fu,通过静电纺丝法还可以制备MnO_(2)-PDA-5-Fu/PVA微球。通过戊二醛交联赋予静电纺丝微球水稳定性。这一复合微球材料具有优异的光热转换性能、可控的药物缓释性能及良好的生物安全性,被应用于防止术后肿瘤的复发。一方面,在808 nm NIR激光照射下MnO_(2)-PDA-5-Fu/PVA微球的光热转换效率可达到24.5%,实现高效的肿瘤热消融;另一方面,释放出来的5-Fu可杀死术后残余的肿瘤细胞。该研究论证了静电纺丝法制备复合微球的可行性,并证实了这种微球在防止肿瘤术后复发领域的应用潜力,为多功能复合微/纳米材料的设计提供了新策略。In this paper, MnO_(2)-polydopamine(PDA)/polyvinyl alcohol(PVA) and MnO_(2)-PVA-5-fluorouracil(5-Fu)/PVA composite microspheres were prepared by electrospinning. Specifically, dopamine(DA) and KMnO_(4) were added to the PVA solution, where a redox reaction happened between DA and KMnO_(4) to form PDA and MnO_(2). Thus,the MnO_(2)-PDA/PVA microspheres were prepared by electrospinning the MnO_(2)-PDA/PVA solution. MnO_(2)-PDA-5-Fu/PVA microspheres were prepared by electrospinning the MnO_(2)-PDA-5-Fu/PVA solution, which was prepared by directly dissolving 5-Fu in the MnO_(2)-PDA/PVA solution. The water stability of the electrospun microspheres was given by a glutaraldehyde crosslinking method. The composite microspheres have excellent photothermal conversion, controlled drug release and good biosafety, which were used to prevent the recurrence of tumor after the operation. The photothermal conversion efficiency of MnO_(2)-PDA-5-Fu/PVA microspheres reaches 24.5% under the irradiation of808 nm NIR laser, which can achieve the efficient tumor thermal ablation;on the other hand, the released 5-Fu can kill the residual tumor cells after operation. This study confirms the application potential of the microspheres in the field of preventing tumor recurrence, and provides a new strategy for the design of multifunctional composite nanomaterials.

关 键 词：静电纺丝 聚乙烯醇 聚多巴胺 光热治疗 肿瘤治疗 

分 类 号：TB332[一般工业技术—材料科学与工程]