白细胞介素-22在慢性阻塞性肺疾病稳定期患者外周血中的变化及其作用机制  

作　　者：赵娜 冷报浪[1] 王海燕[1] 徐佳 

机构地区：[1]杭州市第三人民医院,310000

出　　处：《浙江临床医学》2021年第6期837-838,共2页Zhejiang Clinical Medical Journal

基　　金：杭州市卫生科技计划项目(A20200248)。

摘　　要：目的探讨白细胞介素-22(IL-22)在慢性阻塞性肺疾病(COPD)稳定期患者外周血中的变化及其作用机制、方法纳入COPD稳定期患者30例(观察组)和同期健康体检者28例(对照组),采用酶联免疫吸附试验(ELISA)检测患者的血清IL-22、IL-8水平及白细胞总计数、中性粒细胞计数,观察检测指标的变化并进行相关性分析。结果观察组患者的血清IL-22、IL-8表达水平均高于正常对照组(P<0.05),观察组外周血的中性粒细胞计数显著高于正常对照组(P<0.05)。Pearson相关分析显示,COPD稳定期患者的血清IL-22水平与1L-8水平呈正相关(r=0.313,P<0.05),血清IL-8水平与中性粒细胞计数呈正相关(r=0.683,P<0.05)。结论IL-22可能通过增加趋化因子IL-8招募中性粒细胞至受损部位,引起中性粒细胞气道炎症而参与COPD发病机制。Objective To explore the changes of interleukin-22 in peripheral blood of patients with stable chronic obstructive pulmon«iry disease and its mechanism of action.Methods Thirty patients with stable COPD(observation group)and 28 healthy subjects(control group)were enrolled.Enzyme-linked immunosorbent assay(ELISA)was used to detect serum IL-22 and IL-8 levels,total white blood cell count,and medium Count of neutrophils,observe the changes in detection indicators and perform correlation analysis.Results The senim IL-22 and IL-8 expression levels of the observarion group were higher than those of the normal control group(P<0.05),and the peripheral blood neutrophil count of the observation group was significantly higher than that of the normal control group(P<0.05).Pearson correlation analysis showed that senim IL-22 levels in patients with stable COPD were positively correlated with IL-8 levels(r=0.313,P<0.05),and senim IL-8 levels were positively correlated with neutrophil counts(r=0.683,P<0.05).Conclusion IL-22 may increase the chemokine IL-8 and recruit neutrophils to damaged parts to cause neutrophil airway inflammarion and participate in the pathogenesis of COPD.

关 键 词：白细胞介素-22 慢性阻塞性肺疾病 白细胞介素-8 中性粒细胞 

分 类 号：R56[医药卫生—呼吸系统]