视觉功能减弱增强小鼠听觉恐惧条件反射  

Weakening Visual Function Enhances Auditory Fear Conditioning in Mice

作　　者：付娟 赵旭东 刘田娥[3] 马漫修 孙华英 张波 郑希耕 FU Juan;ZHAO Xu-Dong;LIU Tian-E;MA Man-Xiu;SUN Hua-Ying;ZHANG Bo;ZHENG Xi-Geng(College of Biological and Environmental Engineering,Binzhou University,Binzhou 256600,China;Hefei Comprehensive National Science Center,Institute of Artificial Intelligence,Hefei 230026,China;State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai 200031,China;Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China;College of Chinese Materia Medica,Yunnan University of Chinese Medicine,Kunming 650200,China;Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical University,Guilin 541199,China)

机构地区：[1]滨州学院生物与环境工程学院,滨州256600 [2]合肥综合性国家科学中心人工智能研究院,合肥230026 [3]中国科学院生物物理研究所,北京100101 [4]中国科学院脑科学与智能技术卓越创新中心,上海200031 [5]中国科学院心理研究所心理健康重点实验室,北京100101 [6]云南中医药大学中药学院,昆明650200 [7]桂林医学院,广西脑与认知神经科学重点实验室,桂林541199

出　　处：《生物化学与生物物理进展》2021年第6期709-714,共6页Progress In Biochemistry and Biophysics

基　　金：滨州学院博士基金(2016Y18);滨州学院重大课题(2020ZD01);国家自然科学基金(31730039);国家重点研发计划(2020AAA0105601,2019YFA0707103);国家自然科学基金青年项目(81703497);中国科学院战略重点研究计划(XDB32010300,ZD-BS-LY-SM028);广西自然科学基金(2020GXNSFAA297134);广西科技基地与人才专项(桂科-AD20238023)资助

摘　　要：作为一种高级认知活动,视觉功能减弱是否影响听觉恐惧条件化学习目前还不清楚.本文以突变体rd/rd、cl/cl小鼠为视觉功能减弱组,研究视觉功能减弱是否对听觉巴甫洛夫条件化恐惧反应有影响.在恐惧条件化、恐惧消退和消除记忆再现阶段记录了僵直行为.研究结果表明,视觉功能的减弱更有利于小鼠听觉恐惧条件化的建立.文中讨论了出现此结果的可能神经机制.As advanced cognitive activities,it is poorly understood if visual weakening affects auditory fear conditioning.Here we investigated the responses in auditory Pavlovian fear conditioning,using mutant rd/rd,cl/cl mice as visual weakening group.Freezing behaviors were recorded during fear conditioning,fear extinction,and extinction recall phases.The results indicated that mice with shape vision deprivation are more conducive to auditory fear conditioning.We discuss the possible neuro-mechanism of visual-auditory system interactions.

关 键 词：视觉功能减弱 小鼠 听觉恐惧条件化 

分 类 号：Q42[生物学—神经生物学]