原发性干燥综合征患者生活质量影响因素及与焦虑抑郁的关系  

Factors influencing quality of life of patients with primary Sjogren’s syndrome and their relationship with anxiety and depression

作　　者：王秀涛[1] 秦灵芝[2] 夏明荣 王培[1] Wang Xiutao;Qing Lingzhi;Xia Minrong;Wang Pei(Departmentof Rheumatology and Immunology,Henan Provincial People’s Hospital,Zhengzhou 450003,China;Department of Neurology,Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院风湿免疫科,郑州450003 [2]河南省人民医院神经内科,郑州450003

出　　处：《中国实用医刊》2021年第10期9-12,共4页Chinese Journal of Practical Medicine

基　　金：河南省医学科技攻关项目(201702180)。

摘　　要：目的:探讨原发性干燥综合征(PSS)患者生活质量影响因素及与焦虑抑郁的关系。方法:抽取2018年3月至2020年3月就诊于河南省人民医院的PSS患者176例,设为PSS组;另筛选同期在同一医院普通内科门诊就诊患者176例,设为对照组。采用健康调查简表(SF-36)评估患者的生活质量,医院焦虑抑郁量表(HADS)评估两组患者焦虑抑郁状况,记录并比较症状评分、多系统侵犯和并发症情况,并进行统计学分析。结果:与对照组比较,PSS组SF-36各方面评分均降低,HADS焦虑评分(HAS评分)、HADS抑郁评分(HDS评分)升高(P<0.05)。对女性PSS患者,疼痛和疲劳乏力高评分与SF-36生理健康低得分相关;疲劳乏力高评分与心理健康低得分相关。对PSS患者,疼痛和疲劳乏力评分与HAS和HDS评分升高有相关性,低龄与HAS高评分有相关性,皮肤干燥高评分与HDS评分升高有相关性。结论:PSS患者的生活质量降低,焦虑及抑郁发生率升高。疼痛、疲劳乏力可导致生活质量下降并诱发焦虑抑郁情绪。Objective To investigate the factors influencing quality of life of patients with primary Sjogren’s syndrome(PSS)and their relationship with anxiety and depression.Methods A total of 176 patients with PSS who were admitted to Henan Provincial People’s Hospital from March 2018 to March 2020 were selected as the PSS group.Another 176 outpatients in the same hospital during the same period were selected as the control group.The MOS 36-item short-form health survey(SF-36)was used to assess the quality of life of the two groups,and hospital anxiety and depression scale(HADS)was adopted to assess the degree of anxiety and depression of the two groups.The general data of the two groups including symptom score,system involvement and complications were recorded and compared for further statistical analysis.Results The SF-36 score of PSS group was lower than that of control group,and the hospital anxiety scale(HAS)and hospital depression scale(HDS)of PSS group were higher than those of control group(P<0.05).For female PSS patients,there was a significant correlation of the high scores of pain and fatigue with the low scores of SF-36 physical health;high scores of fatigue were correlated with low scores of mental health.For PSS patients,pain and fatigue were related to the increase of has and HDS scores.There was a correlation between lower age patients and higher HAS score.And there was a correlation between high dry skin score and high HDS score.Conclusions Patients with PSS have poor quality of life,and high incidence of anxiety and depression.Pain and fatigue can promote the decline of quality of life and induce anxiety and depression.

关 键 词：焦虑 抑郁 原发性干燥综合征 

分 类 号：R593.2[医药卫生—内科学]