阿莫西林-克拉维酸钾治疗难治性支气管炎的效果观察  

Effect of amoxicillin-clavulanate potassium in the treatment of refractory bronchitis

作　　者：王连亮 崔丽 张伟立 Wang Lianliang;Cui Li;Zhang Weili(Department of Pharmacy,the Third Provincial People’s Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省直第三人民医院药剂科,郑州450000

出　　处：《中国实用医刊》2021年第10期104-107,共4页Chinese Journal of Practical Medicine

摘　　要：目的:探讨阿莫西林-克拉维酸钾治疗难治性支气管炎的临床效果。方法:抽取2018年7月至2020年7月河南省直第三人民医院收治的153例难治性支气管炎患者为研究对象,应用随机数字表法将其分为对照组(76例)和观察组(77例)。对照组患者予以阿莫西林-克拉维酸钾静脉滴注进行治疗,观察组患者予以阿莫西林-克拉维酸钾序贯疗法进行治疗。比较两组患者治疗效果、治疗情况(住院治疗时间、治疗费用),比较两组患者治疗前、治疗7 d后炎症因子水平如超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、白细胞介素-4(IL-4),比较两组患者治疗过程中不良反应情况。结果:治疗7 d后,两组患者治疗效果比较差异未见统计学意义(P>0.05);观察组患者住院时间、治疗费用低于对照组(P<0.05);治疗7 d后,两组患者hs-CRP、PCT、IL-4水平较治疗前下降,且观察组低于对照组(P<0.05);治疗期间,观察组患者腹泻发生率低于对照组(P<0.05),两组患者皮疹、呕吐、腹痛发生率比较差异未见统计学意义(P>0.05)。结论:阿莫西林-克拉维酸钾静脉滴注与序贯疗法对难治性支气管炎疗效相近,但序贯疗法可显著减少患者住院治疗时间及治疗费用,且对患者炎症因子水平改善效果更显著,且能在一定程度减少患者用药期间不良反应。Objective To explore the clinical effects of amoxicillin-clavulanate potassium in the treatment of refractory bronchitis.Methods A total of 153 patients with refractory bronchitis admitted to the Third Provincial People’s Hospital from July 2018 to July 2020 were selected as the research subjects,and they were divided into control group(n=76)and observation group(n=77)by random number table method.Patients in control group were treated with intravenous drip of amoxicillin-clavulanate potassium,and patients in observation group were treated with amoxicillin-clavulanate potassium sequential therapy.The efficacy and treatment status(thospitalization time,treatment cost)were compared between the two groups after treatment,and the levels of inflammatory factors such as high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),interleukin-4(IL-4)were compared between the two groups before treatment and after 7 days of treatment.The differences in adverse reactions were compared between the two groups during treatment.Results After 7 days of treatment,there were no significant differences in the overall efficacy and total effective rate between the two groups(P>0.05).The hospitalization time and treatment cost of observation group were lower than those of control group(P<0.05).After 7 days of treatment,the levels of hs-CRP,PCT and IL-4 of the two groups were decreased compared with those before treatment,and the levels of observation group were lower than those of control group(P<0.05).During treatment,the incidence rate of diarrhea in observation group was lower than that in control group(P<0.05).There were no significant differences in the occurrence of rash,vomiting and abdominal pain between the two groups(P>0.05).Conclusions Intravenous drip and sequential therapy of amoxicillin-clavulanate potassium both have similar efficacy on refractory bronchitis,but sequential therapy can significantly reduce the hospitalization time and treatment cost,and has a more significant improvement effect on levels of inflamma

关 键 词：阿莫西林 克拉维酸钾 难治性支气管炎 

分 类 号：R562.21[医药卫生—呼吸系统]