ST2、NT-proBNP在心力衰竭病情进展评估的价值研究  

The Values of ST2 and NT-proBNP in Evaluating the Progression of Heart Failure

作　　者：张群英 康娜 唐懿 向俊隽 谢思露 熊大迁[2] ZHANG Qunying;KANG Na;TANG Yi;XIANG Junjun;XIE Silu;XIONG Daqian(Laboratory of Traditional Chinese Medicine Hospital of Longquanyi District, Chengdu 610100,China;Department of Laboratory,Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China)

机构地区：[1]成都市龙泉驿区中医医院检验科,四川成都610100 [2]成都中医药大学附属医院检验科,四川成都610075

出　　处：《标记免疫分析与临床》2021年第6期1012-1015,1031,共5页Labeled Immunoassays and Clinical Medicine

基　　金：四川省卫生与计划生育委员会课题(编号:17PJ393)。

摘　　要：目的探究人基质裂解素-2(ST2)、氨基末端脑钠肽前体(NT-proBNP)在心力衰竭病情进展评估的价值。方法选择我院2019年1月至2019年12月期间收治185例心力衰竭患者作为研究组,同时选择同期在我院进行体检年龄与性别匹配健康者100例作为对照组。测定两组血清ST2、NT-proBNP水平,评估血清ST2、NT-proBNP水平对心力衰竭的诊断价值;研究组患者依据美国纽约心脏病协会(NYHA)心功能标准对心功能进行分级,比较不同心功能分级患者上述血清指标水平及其与心功能的相关性;患者接受抗心衰治疗评估患者治疗效果,比较不同疗效患者治疗前血清指标水平。结果研究组患者血清ST2、NT-proBNP水平显著高于对照组(P<0.05);ROC曲线显示,血清ST2、NT-proBNP水平诊断心力衰竭的曲线下面积(AUC)分别为0.868、0.985,两指标联合检测的AUC为0.996;患者血清ST2、NT-proBNP水平随着心功能分级增加而增加(P<0.05);Spearman相关性分析显示,血清ST2、NT-proBNP水平与NYHA心功能分级正相关(r=0.694、0.752,P<0.05);患者治疗6个月后显效患者治疗前血清ST2、NT-proBNP水平显著高于有效、无效患者,有效患者治疗前血清ST2、NT-proBNP水平显著高于无效患者(P<0.05)。结论血清ST2、NT-proBNP水平对患者心力衰竭诊断价值显著,且与患者病情进展及治疗效果关系密切。Objective To investigate the values of suppression of tumorigenicity 2(ST2)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in evaluating the progression of heart failure.Methods Between January,2019 and December,2019,185 patients with heart failure(study group)and 100 age-matched and gender-matched healthy individuals(control group)were enrolled in the study.The levels of serum ST2 and NT-proBNP were compared between the two groups,and the diagnostic values of the two indicators for heart failure were assessed.The New York Heart Association(NYHA)cardiac function standards were used for cardiac function classification of patients in the study group.The correlation between above-mentioned serum indexes and cardiac function was analyzed,and the serum indexes in patients with different curative effects were compared.Results Serum ST2 and NT-proBNP levels were significantly higher in the study group than those in the control group(P<0.05).ROC curve showed that the AUC values of serum ST2 or NT-proBNP levels for evaluating heart failure were 0.868 and 0.985,respectively.The AUC of combination of the two was 0.996.Serum ST2 and NT-proBNP levels increased with the increase of cardiac function classification(P<0.05).Spearman correlation analysis showed that serum ST2 and NT-proBNP levels were positively correlated with NYHA cardiac function classification(r=0.694,0.752,P<0.05).After 6 months of treatment,serum ST2 and NT-proBNP levels in patients with significantly effective treatment,effective treatment and treatment failure significantly decreased in turn(P<0.05).Conclusion Serum ST2 and NT-proBNP levels are of great value for diagnosing heart failure,and they are closely related to the disease progression and the curative effect.

关 键 词：人基质裂解素-2 N段脑钠肽前体 心力衰竭 病情进展 

分 类 号：R541.6[医药卫生—心血管疾病]