微针导入药物技术在增生性瘢痕防治中的应用  

Application of micro-needle drug delivery in the prevention and treatment of hypertrophic scar

作　　者：刘伟源[1] 区鉴连 钟燕[1] 梁惠贤[1] 胡开艺 许贤君 陈燕图 Liu Weiyuan;Qu Jianlian;Zhong Yan;Liang Huixian;Hu Kaiyi;Xu Xianjun;Chen Yantu(Department of Burns&Plastic Surgery,Wuzhou Red Cross Hospital,Wuzhou 543002,Guangxi,China)

机构地区：[1]广西梧州市红十字会医院烧伤整形外科,广西梧州543002

出　　处：《右江民族医学院学报》2021年第3期344-346,350,共4页Journal of Youjiang Medical University for Nationalities

基　　金：广西壮族自治区自筹经费科研课题(Z20170641)。

摘　　要：目的研究使用微针导入药物技术防治增生性瘢痕的临床效果。方法选择增生性瘢痕病人150例,按入院顺序随机分成3个小组,即对照组、观察组1、观察组2,每组人数都为50例;对照组实施外积雪苷软膏诊治,观察组1实施微针导入积雪苷软膏诊治,观察组2实施微针导入氟尿嘧啶诊治。对比三组治疗前与治疗后9个月的临床效果、VSS分数与POSAS分数,监测病人出现的并发症状。结果观察组1的总有效率是84.00%,观察组2为92.00%,都显著优于对照组的58.00%,差异有统计学意义(P<0.05)。治疗前三组的VSS分数、POSAS分数均显著高于治疗后9个月,且治疗后对照组的分数又显著高于两观察组,差异有统计学意义(P<0.01),其中观察组1又多于观察组2,差异有统计学意义(P<0.05)。三组病人都未产生皮肤过敏的并发症状,观察组2的病人没有产生肝肾功能问题等并发症状。结论微针导入药物技术能显著增强药物治疗效果,可更好地展现出药物的效果,能进一步防止瘢痕的生成,简洁且无副作用,可以在临床中广泛运用。Objective To study the clinical effect of drug delivery by micro-needle in the prevention and treatment of hypertrophic scar.Methods A total of 150 patients with hypertrophic scars were selected and randomly divided into three groups according to their admission time,namely,the control group,observation group 1 and observation group 2,with 50 patients in each group.The control group was treated with Centella Triterpenes Cream.Observation group 1 was treated with micro-needle delivery of Centella Triterpenes Cream,and observation group 2 was treated with micro-needle delivery of fluorouracil.The clinical effects,VSS scores and POSAS scores were compared between three groups before treatment and at 9 months after treatment.And concurrent symptoms were also monitored.Results The total effective rate of observation group 1 was 84.00%,and that of observation group 2 was 92.00%.Both rates were significantly higher than that of the control group(58.00%),with statistically significant differences(P<0.05).The VSS scores and POSAS scores of three groups before treatment were all significantly higher than those at 9 months after treatment,and after treatment the scores of the control group were significantly higher than those of two observation groups,showing significant differences(P<0.01).And observation group 1 had higher scores than observation group 2,with statistically significant difference(P<0.05).Patients in the three groups did not develop concurrent symptoms of skin allergy.Patients in observation group 2 did not develop concurrent symptoms such as problems of liver and kidney function.Conclusion The micro-needle technology for drug delivery can significantly enhance the effect of drug treatment and further prevent the formation of scar.It is simple and has no side effects,and can be widely used in clinical practice.

关 键 词：微针 增生性瘢痕 积雪苷软膏 氟尿嘧啶 

分 类 号：R622[医药卫生—整形外科]