探讨参芪地黄汤抗药源性肾病作用机制的网络药理学方法  

Investigation of network pharmacological method of Shenqi Dihuang Decoction against drug-induced nephropathy

作　　者：李向荣 李向新 邵光新 LI Xiang-rong;LI Xiang-xin;SHAO Guang-xin(Department of Pharmacy,Shanghai Yangpu District Kongjiang Hospital,Shanghai 200093,China;不详)

机构地区：[1]上海市杨浦区控江医院药剂科,上海200093 [2]上海市浦东新区光明中医院

出　　处：《医药论坛杂志》2021年第7期12-17,共6页Journal of Medical Forum

基　　金：上海市卫生和计划生育委员会基金(201640383)。

摘　　要：目的本研究旨在通过网络药理学方法探讨参芪地黄汤治疗药源性肾病的作用机制。方法对参芪地黄汤的有效成分进行全面文献检索,确定相应靶点,并从多个数据库中获得已知的药源性肾病靶点。建立蛋白质相互作用网络,分析参芪地黄汤靶点与已知治疗药源性肾病的靶点之间的关系。结果 STS、MAOB、CA2和BMP2可被20种化合物调控,可能是参芪地黄汤中重要的复合靶点。细胞因子(VEGF、CCR2、TGF-β、PKC)、氧化应激和炎症是药源性肾病发生的关键因素,涉及显著差异表达的最丰富的途径是TNF信号通路、类固醇激素生物合成和VEGF信号通路。结论本研究从整体角度对参芪地黄汤治疗药源性肾病的药理和分子机制进行了部分验证和预测。为实验研究补充了理论基础,拓展了参芪地黄汤在临床上的合理应用。Objective To explore the mechanism of Shenqi Dihuang decoction in the treatment of drug-induced nephropathy by network pharmacology.Methods The effective components of Shenqi Dihuang Decoction were searched comprehensively, the corresponding targets were determined, and the known drug-induced nephropathy targets were obtained from multiple databases. Objective to establish protein interaction network and analyze the relationship between the target of Shenqi Dihuang decoction and the known target of drug-induced nephropathy.Results STS, MAOB, Ca2 and BMP2 can be regulated by 20 compounds, which may be the important target of Shenqi Dihuang decoction. Cytokines(VEGF, CCR2, TGF-β, PKC), oxidative stress and inflammation are the key factors of drug-induced nephropathy. The most abundant pathways involving significant differential expression are TNF signaling pathway, steroid hormone biosynthesis and VEGF signaling pathway.Conclusion This study verified and predicted the pharmacological and molecular mechanism of Shenqi Dihuang decoction in the treatment of drug-induced nephropathy. The theoretical basis is supplemented for experimental research, and the reasonable application of Shenqi Dihuang decoction in clinical practice is expanded.

关 键 词：药源性肾病 急性肾功能衰竭 药物肾毒性 网络药理学 参芪地黄汤 

分 类 号：R285[医药卫生—中药学]