成都市不同人口学特征单采血小板献血者的血液检验不合格情况调查  

Investigation on unqualified apheresis platelet detection of voluntary apheresis platelet donors with different demographic characteristics in Chengdu

作　　者：李艳[1] 洪缨[1] 万浬科[1] 赵玉伟[1] 张蓝江[1] 肖湘[1] 冯伟[1] Li Yan;Hong Ying;Wan Like;Zhao Yuwei;Zhang Lanjiang;Xiao Xiang;Feng Wei(Chengdu Blood Center,Chengdu 610041,Sichuan Province,China)

机构地区：[1]成都市血液中心,610041

出　　处：《国际输血及血液学杂志》2021年第2期178-184,共7页International Journal of Blood Transfusion and Hematology

基　　金：2020年四川省卫生健康委员会科研课题(20PJ231)。

摘　　要：目的探讨成都市单采血小板无偿献血者的人口学特征及血液检验不合格情况。方法选择2015年1月至2019年12月,于成都市血液中心参加单采血小板捐献的44508例无偿献血者为研究对象。本组献血者共计捐献112836人次单采血小板;其年龄为18~60岁;男性献血者为31260例,女性为13248例。对本中心血站管理信息系统的献血者人口统计学资料及血液检验结果,采用回顾性分析方法。其中,献血者的人口学特征包括性别、年龄、单采血小板捐献次数、文化程度、职业;血液检验项目包括丙氨酸氨基转氨酶(ALT)、乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)、梅毒螺旋体(TP)及人类免疫缺陷病毒(HIV)。不同人口学特征献血者的血液检验不合格率比较,采用χ^(2)检验。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》要求,并且于献血前与所有献血者签署《献血者知情同意书》。结果①本组44508例单采血小板无偿献血者的血液检验总不合格率为4.96%(2206/44508)。不同性别、年龄、单采血小板捐献次数、文化程度及职业献血者的血液检验不合格率分别比较,差异均有统计学意义(χ^(2)=32.648、108.012、390.095、168.835、122.255,P<0.001、0.001、0.001、0.001、0.001)。②男性献血者的ALT检验不合格率显著高于女性,并且差异有统计学意义[1.12%(351/31260)比0.17%(23/13248),χ^(2)=100.618,P<0.001]。不同年龄段献血者中,18~25岁献血者的ALT、HBV、HCV、HIV检验不合格率最高,36~45岁者献血者TP检验不合格率最高,不合格率分别为1.01%(138/13688)、1.85%(253/13688)、1.63%(223/13688)、0.64%(87/13688)、1.79%(141/7898),并且不同年龄段献血者的上述检验不合格率分别比较,差异均有统计学意义(χ^(2)=22.287、51.130、51.591、32.236、41.021,P<0.001、0.001、0.001、0.001、0.001)。初次单采血小板献血者的HBV、HCV、TP、HIV不合格率分别为1.57%(537/34264Objective To explore demographic distribution and unqualified blood screening of voluntary apheresis platelet donors in Chengdu.Methods From January 2015 to December 2019,a total of 44508 voluntary blood donors who participated in apheresis platelet donation in Chengdu Blood Center were selected as research subjects.These voluntary blood donors donated a total of 112836 apheresis platelets.The age range of blood donors was 18-60 years old.There were 31260 male,and 13248 female blood donors.Using retrospective analysis methods,demographic data and results of blood detection were collected through the blood station management information system of Chengdu Blood Center.The demographic data included gender,age,number of apheresis platelet donations,education level and occupation.Blood detection included alanine transaminase(ALT),hepatitis B virus(HBV)detection,hepatitis C virus(HCV),Treponema pallidum(TP)and human immunodeficiency virus(HIV)detection.The Chi-square test was used to compare the unqualified rate of blood detection among blood donors with different demographic characteristics.The procedure followed in this study were in accordance with the requirements of the World Medical Association Declaration of Helsinki revised in 2013.And the Informed Consent of Blood Donors were signed with all blood donors before donation.Results①The total unqualified rate of blood detection in 44508 platelet apheresis donors was 4.96%(2206/44508).Unqualified blood detection rates of blood donors with different gender,age,number of apheresis platelet donations,education level,and occupation were compared,and the differences were statistically significant(χ^(2)=32.648,108.012,390.095,168.835,122.255;P<0.001,0.001,0.001,0.001,0.001).②Unqualified rate of ALT detection in male blood donors was higher than that in female blood doners,and the difference was statistically significant[1.12%(351/31260)vs 0.17%(23/13248),χ^(2)=100.118,P<0.001].Among blood donors of different ages,unqualified rate of ALT,HBV,HCV and HIV in blood dono

关 键 词：单采血小板 献血者 检验不合格率 招募 无偿献血 人口学特征 

分 类 号：R457.1[医药卫生—治疗学]