颈动脉彩超及内皮舒张功能与糖尿病冠状动脉粥样硬化狭窄程度的相关性分析  

Correlation of carotid artery color ultrasound and endothelium diastolic function with degree of coronary atherosclerosis stenosis in diabetes mellitus patients

作　　者：刘秀庄 邓秒珍 黄焯明 LIU Xiu-zhuang;DENG Miao-zhen;HUANG Zhuo-ming(Functional Department,Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical University,Foshan 528325,China;Internal Medicine DepartmentⅢ,Xingtan Hospital Affiliated to Shunde Hospital of Southern Medical University,Foshan 528325,China)

机构地区：[1]南方医科大学顺德医院附属杏坛医院功能科,广东佛山528325 [2]南方医科大学顺德医院附属杏坛医院内三科,广东佛山528325

出　　处：《广东医科大学学报》2021年第4期437-440,共4页Journal of Guangdong Medical University

基　　金：佛山市科技攻关项目(No.2016AB003143)。

摘　　要：目的分析2型糖尿病(T2DM)合并冠心病(CHD)患者颈动脉彩超和肱动脉血管内皮功能与T2DM合并CHD患者冠脉狭窄程度的相关性。方法选取156例住院治疗的T2DM合并CHD患者作为研究对象,选取同期住院的50例未合并CHD的T2DM患者作为对照组。对比两组患者动脉内膜中层厚度(IMT)、肱动脉纵切面内径(γ0)和肱动脉血管舒张反应(FMD)值。根据累及的病变冠状动脉支数将观察组患者分为单支病变组和多支病变组,观察及对比两组IMT、γ0、FMD值;根据冠状动脉Gensini积分将观察组患者分为低分组、中分组和高分组,观察及对比各组IMT、γ0、FMD值。分析T2DM合并CHD患者IMT和FMD与冠脉狭窄程度的相关性。结果观察组患者的IMT、γ0高于对照组,FMD低于对照组(P<0.05)。多支病变组患者的IMT、γ0高于单支病变组,FMD低于单支病变组。高分组IMT、γ0值最高,中分组次之,低分组最低;高分组FMD值最低,中分组次之,低分组最高(P<0.05)。Gensini积分与IMT呈正相关,与FMD呈负相关(P<0.01)。结论颈动脉彩超及内皮舒张功能检测可初步反映T2DM合并CHD患者的冠状动脉粥样硬化狭窄程度。Objective To analyze the correlation of carotid artery color ultrasound and endothelium diastolic function with degree of coronary atherosclerosis stenosis in Type 2 diabetes mellitus(T2DM)patients complicated with coronary heart disease(CHD).Methods A total of 156 hospitalized T2DM patients complicated with CHD were selected as the Observation Group and 50 T2DM patients not complicated with CHD that were hospitalized during the same time period were selected as the Control Group.The two groups were observed and compared in terms of the carotid intima-media thickness(IMT),longitudinal section of brachial artery(γ0)and brachial arterial vasodilation(FMD)reaction.The Observation Group was divided into the Single-Vessel Lesion Group and Multi-Vessel Lesion Group according to the number of diseased coronary arteries involved,and the values of IMT,γ0 and FMD were observed and compared between the two groups.The Observation Group was divided into the Low Group,Medium Group and High Group according to the coronary Gensini score,and the values of IMT,γ0 and FMD in each group were observed and compared.The correlation of IMT and FMD to the degree of coronary artery stenosis in T2DM patients complicated with CHD was analyzed.Results IMT andγ0 in the Observation Group were higher than those in the Control Group,and FMD in the Observation Group was lower than that in the Control Group(P<0.05).Gensini score was positively correlated with the IMT and negatively correlated with the FMD,with statistically significant differences(P<0.01).Conclusion Carotid artery color Doppler ultrasound and endothelium diastolic function can preliminarily reflect the degree of coronary artery stenosis in T2DM patients complicated with CHD.

关 键 词：2型糖尿病 冠心病 颈动脉彩超 血管舒张反应 相关性分析 

分 类 号：R455.1[医药卫生—运动医学]