血小板对单核吞噬细胞系统调控机制的研究进展  

Advance in regulatory mechanism of platelet on mononuclear phagocyte system

作　　者：张上上 张媛莉 ZHANG Shang-shang;ZHANG Yuan-li(Guangdong Medical University,Zhanjiang 524001,China;Intensive Care Unit,Affiliated Hospital Of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学,广东湛江524001 [2]广东医科大学附属医院重症医学科,广东湛江524001

出　　处：《广东医科大学学报》2021年第4期499-504,共6页Journal of Guangdong Medical University

摘　　要：除了参与止血、维持血管完整性外,血小板还被视为免疫调节细胞。活化血小板可通过多种机制调控单核-吞噬细胞系统(MPS)炎症表达,在宿主免疫中起重要作用。血小板通过分泌胞外囊泡及生物活性物质,当MPS将其摄取后以间接方式调节炎症表达;此外活化血小板可通过多种膜受体发生结构及数目的变化,进而以直接接触方式调节MPS功能。该文综述了血小板调控MPS的机制。Platelets are also recognized as immune-modulatory cells in addition to participating in haemostasis and maintaining the integrity of blood vessels.Activated platelets can regulate the expression of inflammation in the mononuclear phagocytic system(MPS)through a variety of mechanisms,which plays an important role in host immunity.Platelets can secrete extracellular vesicles and bioactive substances,which can be taken up by MPS to regulate inflammatory expression indirectly.Also,Activated platelets can have changes in structure and quantity through multiple membrane receptors,and then regulate the function of MPS via direct cell-to-cell contact.This paper reviews the mechanism of platelets to regulate the MPS.

关 键 词：血小板 单核-吞噬细胞系统 血小板胞外囊泡 膜表面受体 

分 类 号：R392.12[医药卫生—免疫学]