血清cMyBP-C、Myo水平与老年急性心肌梗死PCI术后心肌无复流的相关性  

Correlation Between Serum cMyBP-C and Myo Levels and Myocardial No-reflow After PCI in Elderly Patients with Acute Myocardial nfarction

作　　者：温珂 WEN Ke(Department of Clinical Laboratory,Pingdingshan,the Second People's Hospital,Pingdingshan 467000 China)

机构地区：[1]平顶山市第二人民医院检验科,河南平顶山467000

出　　处：《内蒙古医学杂志》2021年第6期663-667,共5页Inner Mongolia Medical Journal

基　　金：2019年度河南省医学科技攻关计划(编号:LHGJ20191459)。

摘　　要：目的分析血清心脏型肌球蛋白结合蛋白C(cMyBP-C)、肌红蛋白(Myo)表达与老年急性心肌梗死(AMI)患者经皮冠脉介入术(PCI)后心肌无复流的关系。方法回顾性分析,收集医院2018年3月至2020年5月接受PCI手术治疗的53例术后心肌无复流老年AMI患者资料,纳为心肌无复流组,另收集同期接受PCI术治疗的53例术后心肌复流老年AMI患者资料,纳为心肌复流组。全部老年AMI患者在入院时、PCI术后48 h均接受血清cMyBP-C、Myo检测,相关实验室检测结果、病例资料等完整;统计并比较两组相关基线资料及血清cMyBP-C、Myo水平,分析血清cMyBP-C、Myo表达与老年AMI患者PCI术后心肌无复流的关系。结果 106例老年AMI患者PCI术后48 h cMyBP-C、Myo水平均较入院时降低,差异有统计学意义(P<0.05);心肌无复流老年AMI患者入院时心肌肌钙蛋白I(cTnI)、cMyBP-C、Myo水平均高于心肌复流患者,差异有统计学意义(P<0.05);组间其他基线资料比较差异无统计学意义(P>0.05);经Logistic回归分析结果显示,cMyBP-C、Myo异常表达可能与老年AMI患者PCI术后心肌无复流有关,cMyBP-C、Myo过表达可能是老年AMI患者PCI术后心肌无复流的风险因子(OR>1,P<0.05);绘制ROC曲线发现,血清cMyBP-C、Myo单一及联合预测老年AMI患者PCI术后心肌无复流风险的AUC>0.80,均有一定预测价值。结论老年AMI患者PCI术后心肌无复流可能与血清cMyBP-C、Myo过表达有关,未来可考虑检测患者入院时血清cMyBP-C、Myo表达,辅助评估老年AMI患者PCI术后心肌无复流风险。Objective To analyze the relationship between the expression of serum cardiac myosin binding protein C(cMyBP-C)and myoglobin(Myo)and myocardial no reflow after percutaneous coronary intervention(PCI)in elderly patients with acute myocardial infarction(AMI).Methods A retrospective analysis was conducted,the data of 53 elderly AMI patients who received PCI treatment and didn’t have myocardial reflow from March 2018 to May 2020 in the hospital were collected,included in the myocardial no reflow group,and the data of 53 elderly AMI patients who received PCI treatment and had myocardial reflow in the same period were collected,included in the myocardial reflow group.Serum cMyBPC and Myo were detected in all elderly patients with AMI at admission and48 hours after PCI,and the relevant laboratory test results and medical data were complete;the baseline data and serum cMyBP-C and Myo levels were counted and compared between the two groups,the relationship between the expression of serum cMyBP-C and Myo and myocardial no reflow after PCI in elderly patients with AMI was analyzed.Results The levels of cMyBP-C and Myo in 106 elderly patients with AMI 48 hours after PCI were significantly lower than those at admission,the difference was statistically significant(P<0.05);the levels of cardiac troponin I(cTnI),cMyBP-C and Myo in elderly AMI patients with myocardial no reflow were higher than those in patients with myocardial reflow,the difference was statistically significant(P<0.05);there was no statistical significant difference in other baseline data between the two groups(P>0.05);through Logistic regression analysis,the results showed that the abnormal expression of cMyBP-C and Myo might be related to myocardial no reflow after PCI in elderly patients with AMI,the overexpression of cMyBP-C and Myo might be risk factors of myocardial no reflow after PCI in elderly patients with AMI(OR>1,P<0.05);ROC curve was drawn and showed that the AUC of serum cMyBP-C and Myo alone and in combination in predicting myocardial no reflow

关 键 词：急性心肌梗死 心脏型肌球蛋白结合蛋白C 肌红蛋白 心肌无复流 

分 类 号：R542.22[医药卫生—心血管疾病]