皮肤胶原血管病一例  

A case of cutaneous collagenous vasculopathy

作　　者：刘炳栾 郑炘凯 吴实[1] 徐瑾[1] 邓列华[1] 胡云峰[1] 刘赛君[1] Liu Bingluan;Zheng Xinkai;Wu Shi;Xu Jin;Deng Liehua;Hu Yunfeng;Liu Saijun(Department of Dermatology,The First Affiliated Hospital of Jinan University,Jinan University Institute of Dermatology,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院皮肤科暨南大学皮肤病研究所,广州510630

出　　处：《中华皮肤科杂志》2021年第7期629-631,共3页Chinese Journal of Dermatology

摘　　要：患者女,22岁,小腿皮肤潮红4年,6个月前渐蔓延至整个下肢、前臂。皮肤科检查:下肢及双前臂可见弥漫潮红及扩张的毛细血管,压之褪色。皮损组织病理:网篮状角化过度,基底层色素增加,真皮浅层散在淋巴细胞浸润,未见明显红细胞溢出;PAS染色显示,血管周围可见增厚的均一化物质沉积;免疫组化显示,血管壁增厚,Ⅳ型胶原阳性。诊断:皮肤胶原血管病。A 22-year-old female patient presented with skin flushing in the bilateral legs for 4 years,which gradually spread throughout the whole lower limbs and forearms 6 months ago.Skin examination showed diffuse flushing and dilated capillaries in the lower limbs and both forearms,and the flushing faded after a press.Histopathological examination of the skin lesion on the leg showed hyperkeratosis in a basket-like shape,increased pigmentation in the basal layer,infiltration of the superficial dermis with scattered lymphocytes,with no obvious red blood cell overflow;periodic acid-Schiff staining showed thickened and homogeneous deposits around the blood vessels;immunohistochemical staining showed thickened blood vessel walls and positive staining for typeⅣcollagen.Diagnosis:cutaneous collagenous vasculopathy.

关 键 词：毛细血管扩张 胶原Ⅳ型 皮肤胶原血管病 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]