IL-10启动子区基因多态性与梅毒血清固定易感性的相关性  

The correlation between the polymorphism of IL-10 promoter and the susceptibility of syphilis serum fixation

作　　者：张若晨 郑娜娜 钟连生 Zhang Ruochen;Zheng Nana;Zhong Liansheng(Department of Dermatology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]徐州医科大学附属医院皮肤性病科,221002

出　　处：《中国医师杂志》2021年第6期886-889,共4页Journal of Chinese Physician

摘　　要：目的研究IL-10启动子区-592A/C(rs1800872)和-1082A/G(rs1800896)位点单核苷酸多态性(SNP)与梅毒血清固定易感性之间是否存在关联。方法应用多重单碱基延伸(SNaPshot)技术检测2019年1月至12月就诊于徐州医科大学附属医院收治的123例梅毒血清固定患者、118例梅毒血清转阴患者和120例健康人群对照的IL-10启动子区-592A/C和-1082A/G位点SNP,比较不同研究对象临床特点、基因型及等位基因频率差异。结果血清固定组与血清转阴组和健康对照组年龄、性别差异无统计学意义(P>0.05)。血清固定组与血清转阴组性伴侣数量、初始RPR滴度、分期、吉海反应差异无统计学意义(P>0.05)。在IL-10启动子区-592A/C与-1082A/G位点,血清固定组与血清转阴组和健康对照组比较,基因型及等位基因频率差异均无统计学意义(P>0.05)。结论IL-10启动子区-592A/C和-1082A/G位点SNP与梅毒血清固定易感性之间无显著相关。Objective To explore the association of-592A/C and-1082A/G single nucleotide polymorphism in interleukin(IL)-10 gene with susceptibility to serofast in patients with syphilis.Methods The SNPs of-592A/C and-1082A/g in the promoter region of IL-10 were detected by multiple single base extension(SNaP-shot)assay in 123 patients with syphilis(syphilis group),118 patients with seronegative syphilis(seronegative syphilis group)and 120 healthy controls(healthy control group).The clinical characteristics,genotypes and allele frequencies of different subjects were compared.Results There was no significant difference in age and gender between syphilis group,seronegative syphilis group and healthy control group(P>0.05).There was no significant difference in the number of sexual partners,initial rapid plasma reagin test for syphilis(RPR)titer,stage,and Jihai reaction between the syphilis group and seronegative syphilis group(P>0.05).There was no significant difference in the genotype and allele frequency of-592A/C and-1082A/G in the promoter region of IL-10 between the syphilis group,seronegative syphilis group and the control group(P>0.05).Conclusions There seems to be no evidence for association between-592A/C and-1082A/G single nucleotide polymorphism in IL-10 gene and susceptibility to serofast in patients with syphilis.

关 键 词：白细胞介素10 多态性 单核苷酸 梅毒血清诊断 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]