2-巯基吡啶与醇的催化脱水取代反应——2-吡啶硫醚的绿色合成  

Catalytic Dehydrative Substitution Reaction of 2-Mercaptopyridine with Alcohols Leading to the Green Synthesis of 2-Pyridyl Thioethers

作　　者：于静 张云洁 邢子豪 马献涛 YU Jing;ZHANG Yunjie;XING Zihao;MA Xiantao(College of Chemistry and Chemical Engineering/Green Catalysis&Synthesis Key Laboratory of Xinyang City,Xinyang Normal University,Xinyang 464000,China)

机构地区：[1]信阳师范学院化学化工学院/信阳市绿色催化与合成重点实验室,河南信阳464000

出　　处：《信阳师范学院学报（自然科学版）》2021年第3期462-466,共5页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：河南省科技攻关项目(192102310031);信阳师范学院青年骨干教师资助计划项目(2018GGJS-05);信阳师范学院大学生科研基金项目(2020-DXS-096)。

摘　　要：以廉价易得的醇作为碳源、以摩尔分数10%的对甲苯磺酸作为催化剂,发展了2-巯基吡啶与醇的催化脱水取代反应新方法,用于2-吡啶硫醚化合物的高效、绿色合成,产率高达95%.该方法只需要使用廉价的对甲苯磺酸作为催化剂、无需溶剂,也可以拓展到其他类型杂芳基硫醚的绿色合成.By using the cheap and easily-available alcohol as the alkyl source,10%(mol)p-toluenesulfonic acid as the catalyst,a catalytic dehydrative substitution reaction of 2-mercaptopyridine and alcohols is developed for the green and efficient synthesis of 2-pyridyl thioethers,and the yields of target thioethers are up to 95%.This solvent-free method only requires the cheap and easily-available p-toluenesulfonic acid as the catalyst and can be easily extended to the synthesis of other heteroaryl thioethers.

关 键 词：吡啶硫醚 醇 脱水取代反应 

分 类 号：O626[理学—有机化学]