Innovative color jet 3D printing of levetiracetam personalized paediatric preparations  

作　　者：Zengming Wang Xiaolu Han Ruxin Chen Jingru Li Jing Gao Hui Zhang Nan Liu Xiang Gao Aiping Zheng 

机构地区：[1]Department of Pharmaceutics,Institute of Pharmacology and Toxicology of Academy of Military Medical Sciences,Beijing 100850,China [2]College of Pharmaceutical Sciences,Key Laboratory of Pharmaceutical Quality Control of Hebei Province,Institute of Life Science and Green Development,Hebei University,Baoding 071002,China [3]School of Pharmacy,Xuzhou Medical University,Xuzhou 221000,China

出　　处：《Asian Journal of Pharmaceutical Sciences》2021年第3期374-386,共13页亚洲药物制剂科学（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(No.82073793);the National Major Science and Technology Projects of China(No.2018ZX09721003-007/No.2018ZX09J18107).

摘　　要：3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production.

关 键 词：Color jet 3D printing Paediatric preparations Personalized administration Medicine dosage model Immediate release 

分 类 号：R943[医药卫生—药剂学]