注射用头孢曲松钠临床配伍稳定性研究  

The Stability of Ceftriaxone Sodium for Injection for Clinical Compatibility

作　　者：郑光雅 ZHENG Guang-ya(Central Hospital of Sichuan Provincial Prison Administration,Chengdu 610000,China)

机构地区：[1]四川省监狱管理局中心医院,四川成都610000

出　　处：《海峡药学》2021年第6期62-64,共3页Strait Pharmaceutical Journal

摘　　要：目的考察注射用头孢曲松钠在与临床常用输液配伍后稳定性。方法从关键质量属性:有关物质、含量测定、聚合物、pH值、溶液颜色评价配伍后稳定性。结果注射用头孢曲松钠配伍后在室温6 h下稳定。结论注射用头孢曲松钠在输液中稳定性有限,为了保证用药安全,应引起临床用药注意。OBJECTIVE The essay is to investigate the stability of ceftriaxone sodium for injection after compatibility with clinical common infusion.METHODS The compatibility stability was evaluated in terms of the critical quality attributes such as related substances,content assay,polymers,colours of solution.RESULTS Ceftriaxone sodium for injection was stable at room temperature for 6 hours after compatibility.CONCLUSION The stability of ceftriaxone sodium for injection is limited in other injection.Therefore,in order to ensure drug safety,clinical medication should be paid special attention to.

关 键 词：头孢曲松钠 配伍 稳定性 

分 类 号：R927[医药卫生—药学]