中医药调控Nrf2-ARE信号通路治疗慢性肾脏病的研究进展  

Research Progress of Traditional Chinese Medicine Regulating Nrf2-ARE Signaling Pathway in the Treatment of Renal Diseases

作　　者：官莹洁 赵爱萍[2] GUAN Ying-jie;ZHAO Ai-ping(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;People′s Hospital affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China)

机构地区：[1]福建中医药大学,福建福州350122 [2]福建中医药大学附属人民医院,福建福州350004

出　　处：《海峡药学》2021年第6期91-94,共4页Strait Pharmaceutical Journal

基　　金：国家中医临床研究基地专项课题(JDZX201934);阮诗玮福建省名老中医药专家传承工作室项目(闽卫办中2018:216)。

摘　　要：越来越多研究证实氧化应激在慢性肾脏病的进展中扮演着不可或缺的角色。Nrf2-ARE信号通路是机体抗氧化应激反应的重要应答机制之一,其激活后能启动下游多种保护性基因的转录以增强细胞抗氧化、清除毒物的防御保护作用,已经成为当今肾脏病治疗的重要靶点之一。该文从Nrf2-ARE信号通路的调控机制角度出发,阐述近年来中医药在干预治疗慢性肾脏病中的研究成果和进展,为各种中药单体、中药复方在未来临床中治疗慢性肾脏病提供更多新的思考和方向。More and more studies have confirmed that oxidative stress plays an indispensable role in the development of chronic kidney disease.Nrf2-ARE signaling pathway is one of the important response mechanisms of the body′s antioxidant stress response.After activation,Nrf2-ARE can activate transcription of a variety of downstream protective genes to enhance the defense and protection effect of cellular antioxidant and toxin clearance,which has become one of the important targets in the treatment of renal diseases.From the perspective of the regulatory mechanism of Nrf2-ARE signaling pathway,this paper expounds the research achievements and progress of traditional Chinese medicine in the intervention treatment of chronic kidney disease in recent years,so as to provide more new thoughts and directions for the future clinical treatment of chronic kidney disease by various traditional Chinese medicine monomers and traditional Chinese medicine compounds.

关 键 词：Nrf2-ARE 中医药 糖尿病肾病 狼疮性肾炎 慢性肾脏病 

分 类 号：R969.4[医药卫生—药理学]