肾脏疾病中HGF/c-Met信号通路的研究进展  

Research Progress of HGF/c-Met Signaling Pathway in Renal Diseases

作　　者：谢廷良 陈智婕 于鹤 王向真 任梓润 陈晓乐[2] 张南文[2] 黄燕愉 XIE Ting-liang;CHEN Zhi-jie;YU He;WANG Xiang-zhen;REN Zi-run;CHEN Xiao-le;ZHANG Nan-wen;HUANG Yan-yu(School of Medical Care,Minjiang Teachers College,Fuqing 350300,China;School of Pharmacy,Fujian Medical University,Fuzhou 350122,China;The Second Affiliated Hospital of Xiamen Medical College,Xiamen 361000,China)

机构地区：[1]闽江师范高等专科学校医护学院,福建福清350300 [2]福建医科大学药学院,福建福州350122 [3]厦门医学院附属第二医院,福建厦门361000

出　　处：《海峡药学》2021年第6期95-98,共4页Strait Pharmaceutical Journal

基　　金：国家级大学生创新创业训练计划项目(编号:202010392017X);福建省自然科学基金项目(编号:2019J01306);2019年厦门市医疗卫生指导性项目(编号:3502Z20199065);闽江师范高等专科学校校级常规课题(MKBZ202003)。

摘　　要：肝细胞生长因子(HGF)是一种多肽,作用于各种上皮细胞,调节细胞的生长,运动和形态发生,还能促进损伤器官的组织再生,是器官再生的关键分子。除了肝脏的再生外,在肾脏的再生中也扮演着重要的角色。此外,在各种肾脏疾病中HGF状态的适应性改变也会发生。然而,HGF在各种肾脏疾病作用仍不清楚,HGF的信号通路可能与肾脏疾病有关,现就HGF/c-Met信号通路在肾脏疾病中的研究进展作一综述。Hepatocyte growth factor(HGF)is a polypeptide that acts on various epithelial cells,regulates cell growth,movement and morphogenesis,and promotes tissue regeneration of damaged organs,which is the key molecule of organ regeneration.In addition to liver regeneration,it also plays an important role in kidney regeneration.In addition,adaptive changes in the state of HGF also occur in various kidney diseases.However,the role of HGF in various renal diseases is still unclear,and the signal pathway of HGF may be related to renal diseases.This paper reviews the research progress of HGF/c-Met signaling pathway in renal diseases.

关 键 词：肝细胞生长因子 信号通路 肾脏 疾病 进展 

分 类 号：R969.4[医药卫生—药理学]