血栓前状态相关指标与复发性流产的关系研究  

Study on the Relationship between Prethrombotic State and Recurrent Miscarriage

作　　者：杨春年 官瑞婷[2] YANG Chun-nian;GUAN Rui-ting(Department of Laboratory Medicine,Maternal and Child Health Hospital of Jinjiang City,Fujian Jinjiang,Fujian,362200,China;The Second Affiliated Hospital of Fujian Medical University,Quanzhou,Fujian,362000,China)

机构地区：[1]福建晋江市妇幼保健院检验科,福建晋江362200 [2]福建医科大学附属第二医院,福建泉州362000

出　　处：《血栓与止血学》2021年第4期555-557,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨复发性流产与血栓前状态(PTS)相关指标的关系。方法选择福建晋江市妇幼保健院和福建医科大学附属第二医院于2018年1月~12月期间收治的不明原因复发性流产(URSA)患者200例为观察组(流产次数;2次113例,≥3次87例),同期行健康体检的200例健康者为对照组。抽取空腹肘静脉血取上清液或血浆,测定纤维蛋白原(Fbg)、D二聚体(D-D)、纤溶酶原激活抑制物-1(PAI-1)、组织纤溶酶原激活物(tPA)、P选择素、血小板第四因子(PF4)水平。对比不同组别、不同流产次数患者PTS相关指标差异。结果观察组Fbg、D-D、PAI-1、tPA、P选择素、PF4均高于对照组(P<0.05);流产≥3次组高于2次组(P<0.05)。结论Fbg、D-D、PAI-1、tPA、P选择素、PF4水平与URSA的发生、次数密切相关,采取预防性治疗措施改善上述指标水平,可改善患者的预后。Objective To explore the relationship between recurrent miscarriage and related indicators of prethrombotic state(PTS).Methods A total of 200 patients with unexplained recurrent miscarriage(URSA)admitted to the Jinjiang Maternity and Child Health Hospital of Fujian Province and the Second Affiliated Hospital of Fujian Medical University between January and December 2018 were selected as the observation group(number of miscarriages);113 cases in 2 cases,≥3 times(87 cases),200 healthy people who underwent physical examination during the same period served as control group.Take fasting cubital venous blood to take supernatant or plasma,determine fibrinogen(Fbg),D-dimer(D-D),plasminogen activation inhibitor-1(PAI-1),tissue plasminogen activation(tPA),P-selectin,and platelet factor 4(PF4).Compare the differences in PTS related indicators of patients in different groups and different times of miscarriage.Results Fbg,D-D,PAI-1,tPA,P-selectin,and PF4 in the observation group were all higher than those in the control group(P<0.05);Fg,D-D,PAI-1,tPA,P-selectin,and PF4,Abortion≥3 times group The levels of P-selectin and PF4 were higher than those in the second group,(P<0.05).Conclusion The levels of Fbg,D-D,PAI-1,tPA,P-selectin,and PF4 are closely related to the occurrence and frequency of URSA.Preventive treatment measures to improve the above-mentioned index levels can improve the pregnancy outcome of patients with recurrent miscarriage.

关 键 词：复发性流产 血栓前状态 凝血指标 

分 类 号：R714.21[医药卫生—妇产科学]