小柴胡汤治疗2型糖尿病胃轻瘫(肝郁脾虚型)的效果及对患者胃泌素、生长抑制素的影响  

Xiaochaihu Decoction in the Treatment of Type 2 Diabetic Gastroparesis(Liver Stagnation and Spleen Deficiency Type)and Its Effect on Gastrin and Somatostatin in Patients

作　　者：刘红艳[1] LIU Hongyan(Department of Geriatrics,Tai'an Hospital of Traditional Chinese Medicine,Tai'an,Shandong Province,271000 China)

机构地区：[1]山东省泰安市中医医院老年病科,山东泰安271000

出　　处：《糖尿病新世界》2021年第9期17-21,25,共6页Diabetes New World Magazine

摘　　要：目的分析小柴胡汤在2型糖尿病胃轻瘫(肝郁脾虚型)治疗中的作用。方法选取2017年9月—2019年9月收治的2型糖尿病胃轻瘫(肝郁脾虚型)患者98例,按照抽签法分组,对照组和观察组例数均等,各为49例。对照组用常规西药方案,观察组在对照组基础上使用小柴胡汤,比较总有效率、治疗前后血糖水平、中医证候积分、胃功能指标和氧化应激水平。结果观察组疾病治疗总有效率为95.92%,高于对照组的77.55%,差异有统计学意义(P<0.05);治疗前两组血糖水平、中医证候积分、胃功能指标和氧化应激指标对比,差异无统计学意义(P>0.05),观察组治疗后空腹血糖为(6.54±1.21)mmol/L,餐后2 h血糖为(9.90±1.32)mmol/L,糖化血红蛋白为(5.76±1.12)%,中医证候积分为(6.36±1.06)分,胃泌素水平为(102.24±20.18)ng/L,胃动素水平为(332.18±70.48)ng/L,丙二醛为(3.78±1.12)nmol/mL,晚期氧化蛋白产物为(48.12±8.45)μmol/mL,低于对照组的(7.32±1.18)mmol/L、(10.82±1.56)mmol/L、(6.48±1.15)%、(6.94±1.06)分、(116.78±22.42)ng/L、(380.32±72.96)ng/L、(4.52±1.32)nmol/mL、(53.36±9.21)μmol/mL,生长抑素水平为(52.16±12.24)ng/L,超氧化物歧化酶为(29.32±3.68)U/mL,高于对照组的(45.21±10.48)ng/L和(27.12±3.54)U/mL,差异有统计学意义(P<0.05)。结论在2型糖尿病胃轻瘫(肝郁脾虚型)患者治疗中使用小柴胡汤,效果明显,可获得理想的血糖控制效果,降低证候积分,对胃功能指标有理想的改善作用,也可改善氧化应激状态,可推广。Objective To analyze the effect of Xiaochaihu Decoction in the treatment of type 2 diabetic gastroparesis(stagnation of liver and spleen deficiency).Methods A total of 98 patients with type 2 diabetic gastroparesis(hepatic depression and spleen deficiency)who were admitted from September 2017 to September 2019 were selected and divided into groups according to the lottery method.The number of cases in the control group and the observation group was equal,with 49 cases in each.The control group was treated with conventional western medicine,and the observation group was used in combination with Xiaochaihu Decoction on the basis of the control group to compare the total effective rate,blood glucose level before and after treatment,TCM syndrome score,gastric motility index and oxidative stress level.Results The total effective rate of disease treatment in the observation group was 95.92%,which was higher than 77.55%in the control group.The difference between the groups was statistically significant(P<0.05);compared the blood glucose level,TCM syndrome score,gastric function index and oxidative stress index before treatment in the two groups,the difference was not statistically significant(P>0.05).The fasting blood glucose of the observation group after treatment was(6.54±1.21)mmol/L,the blood glucose of 2 h after meal was(9.90±1.32)mmol/L,and the glycosylated hemoglobin was(5.76±1.12)%,the integral was(6.36±1.06)points,the gastrin level was(102.24±20.18)ng/L,the motilin level was(332.18±70.48)ng/L,and the malondialdehyde was(3.78±1.12)nmol/mL,the product of late oxidized protein was(48.12±8.45)μmol/mL,lower than the control group’s(7.32±1.18)mmol/L,(10.82±1.56)mmol/L,(6.48±1.15)%,(6.94±1.06)points,(116.78±22.42)ng/L,(380.32±72.96)ng/L,(4.52±1.32)nmol/mL,(53.36±9.21)μmol/mL,somatostatin level was(52.16±12.24)ng/L,superoxide dismutase was(29.32±3.68)U/mL,higher than the control group(45.21±10.48)ng/L and(27.12±3.54)U/mL,the difference was statistically significant(P<0.05).Conclusion The use of

关 键 词：小柴胡汤 2型糖尿病 胃轻瘫 血糖水平 中医证候积分 胃功能 氧化应激指标 

分 类 号：R587.2[医药卫生—内分泌]