甘精胰岛素对初发2型糖尿病患者血清抵抗素水平的影响  

The Effect of Insulin Glargine on Serum Resistin Level in Newly Diagnosed Type 2 Diabetic Patients

作　　者：刘沛沛[1] LIU Peipei(Department of Pharmacy,Tai'an Hospital of Traditional Chinese Medicine,Tai'an,Shandong Province,271000 China)

机构地区：[1]山东省泰安市中医医院药剂科,山东泰安271000

出　　处：《糖尿病新世界》2021年第9期104-107,共4页Diabetes New World Magazine

摘　　要：目的分析甘精胰岛素对初发2型糖尿病患者血清抵抗素水平的影响。方法选取2018年5月—2020年5月90例初发2型糖尿病患者,根据不同的治疗方法,将所有患者分为对照组(n=45,接受预混胰岛素治疗)与观察组(n=45,接受甘精胰岛素治疗)。将两组治疗后的胰岛素指功能指标以及血糖水平进行对比。结果两组治疗前的空腹胰岛素(fasting serum insulin,FINS)、胰岛β细胞功能指数(index ofβ-cell function in HOMA,HOMA-β)、胰岛素抵抗指数(homeostasis model-insulin resistance,HOMA-IR)水平相比,差异无统计学意义(P>0.05)。治疗后,相比于对照组,观察组的FINS、HOMA-IR水平明显较低,差异有统计学意义(P<0.05);相比于对照组,观察组的HOMA-β水平明显较高,差异有统计学意义(P<0.05)。两组治疗前的空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖水平(2 h postprandial blood glucose,2 hPG)、糖化血红蛋白(hemoglobin A1c,HbA1c)水平相比,差异无统计学意义(P>0.05)。治疗后,相比于对照组,观察组的FPG、2 hPG、HbA1c水平明显较低,差异有统计学意义(P<0.05)。结论甘精胰岛素有利于改善初发2型糖尿病患者的血糖水平,且可以有效保护胰岛β细胞功能,增加机体对胰岛素的敏感性,继而稳定血糖水平。Objective To analyze the effect of insulin glargine on serum resistin levels in newly diagnosed type 2 diabetic patients.Methods Ninety patients with newly diagnosed type 2 diabetes were selected from May 2018 to May 2020.According to different treatment methods,all patients were divided into a control group(n=45,receiving premixed insulin treatment)and an observation group(n=45,receiving insulin glargine treatment).The insulin finger function indexes and blood glucose levels of the two groups after treatment were compared.Results Fasting serum insulin(FINS),index ofβ-cell function in HOMA(HOMA-β),and insulin resistance index(homeostasis model-insulin resistance,HOMA-IR)before treatment in the two groups had no difference in level,the difference was not statistically significant(P>0.05).After treatment,compared with the control group,the FINS and HOMA-IR levels in the observation group were significantly lower,the difference was statistically significant(P<0.05);compared with the control group,the HOMA-βlevels in the observation group were significantly higher,the difference was statistically significant(P<0.05).The fasting plasma glucose(FPG),2 h postprandial blood glucose(2 hPG),and hemoglobin A1c(HbA1c)levels before treatment were not different between the two groups,the difference was not statistically significant(P>0.05).After treatment,compared with the control group,the levels of FPG,2 hPG,and HbAlc in the observation group were significantly lower,the difference was statistically significant(P<0.05).Conclusion Insulin glargine is beneficial to improve the blood glucose level of patients with newly-onset type 2 diabetes,and can effectively protect the function of pancreaticβ-cells,increase the body's sensitivity to insulin,and then stabilize the blood glucose level.

关 键 词：2型糖尿病 甘精胰岛素 血清抵抗素水平 

分 类 号：R587.1[医药卫生—内分泌]