Advances in the pathogenesis of Alzheimer’s disease:a re-evaluation of amyloid cascade hypothesis  

作　　者：Suzhen Dong Yale Duan Yinghe Hu Zheng Zhao 

机构地区：[1]Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development,East China Normal University,Shanghai 200062,China [2]Institute of Chemical and Translational Genomics,East China Normal University,Shanghai 200062,China [3]Key Laboratory of Brain Functional Genomics,Ministry of Education,Shanghai Key Laboratory of Brain Functional Genomics,East China Normal University,3663 Zhongshan Road(N),Shanghai 200062,China

出　　处：《Translational Neurodegeneration》2012年第1期140-151,共12页转化神经变性病（英文）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.31171019,No.81173108 and No.31000574);the Opening Projects of Shanghai Key Laboratory of Brain Functional Genomics and Key Laboratory of Brain Functional Genomics(East China Normal University),Ministry of Education.

摘　　要：Alzheimer’s disease(AD)is a common neurodegenerative disease characterized clinically by progressive deterioration of memory,and pathologically by histopathological changes including extracellular deposits of amyloid-beta(A-beta)peptides forming senile plaques(SP)and the intracellular neurofibrillary tangles(NFT)of hyperphosphorylated tau in the brain.This review focused on the new developments of amyloid cascade hypothesis with details on the production,metabolism and clearance of A-beta,and the key roles of some important A-beta-related genes in the pathological processes of AD.The most recent research advances in genetics,neuropathology and pathogenesis of the disease were also discussed.

关 键 词：Alzheimer’s disease A-BETA APP BACE1 PRESENILINS ApoE Neprilysin/insulin-degrading enzyme 

分 类 号：R74[医药卫生—神经病学与精神病学]