丹红注射液治疗慢性肺源性心脏病临床研究  

Clinical Study on Danhong Injection for Chronic Pulmonary Heart Disease

作　　者：范红娟 张向明 汪根良 FAN Hongjuan;ZHANG Xiangming;WANG Genliang

机构地区：[1]金华市婺城区第一人民医院急诊科,浙江金华321075

出　　处：《新中医》2021年第12期67-70,共4页New Chinese Medicine

基　　金：金华市科学技术公益类项目(2018-4-090)。

摘　　要：目的:观察丹红注射液对慢性肺源性心脏病患者的治疗效果。方法:选取慢性肺源性心脏病加重患者71例,根据随机数表法分为对照组及观察组。对照组采用甲磺酸酚妥拉明治疗,观察组在对照组基础上联合丹红注射液治疗。对比2组血气指标、肺功能、炎症因子、N-末端脑钠素前体(NT-proBNP)水平及不良反应情况。结果:与同组治疗前比较,治疗后2组动脉血氧分压(PaO_(2))、第1秒用力呼气容积(FEV_(1))、第1秒用力呼气容积比用力肺活量(FEV_(1)/FVC)水平均升高(P<0.05),二氧化碳分压(PaCO_(2))及血清肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)、超敏C-反应蛋白(hs-CRP)、NT-proBNP、脑钠肽(BNP)、心肌肌钙蛋白I(cTnI)水平均降低(P<0.05)。与对照组治疗后比较,观察组治疗后PaO_(2)、FEV_(1)、FEV_(1)/FVC水平更高(P<0.05),PaCO_(2)及血清TNF-α、hs-CRP、ET-1、NT-proBNP、cTnI、BNP水平更低(P<0.05)。治疗期间2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:丹红注射液联合甲磺酸酚妥拉明治疗慢性肺源性心脏病,可有效减轻患者血气指标、肺功能,降低炎症因子水平,改善患者心功能。Objective:To observe the curative effect of Danhong injection for patients with chronic pulmonary heart disease.Methods:A total of 71 cases of patients with aggravated chronic pulmonary heart disease were selected and divided into the control group and the observation group according to the random number table method.The control group was treated with phentolamine mesylate,and the observation group was additionally treated with Danhong injection based on the treatment of the control group.The levels of blood gas indexes,lung function,inflammatory factors and N-terminal probrain natriuretic peptide(NT-proBNP)as well as adverse reactions in the two groups were compared.Results:After treatment,the levels of partial pressure of oxygen in arterial-blood(PaO_(2)),forced expiratory volume in one second(FEV_(1))and the percentage of forced expiratory volume in one second to forced vital capacity(FEV_(1)/FVC)in the two groups were increased when compared with those before treatment(P<0.05);the levels of tumor necrosis factor-α(TNF-α),endothelin-1(ET-1),hypersensitivity C-reaction protein(hs-CRP),NT-proBNP,brain natriuretic peptide(BNP)and cardiac troponin I(cTnI)in serum as well as carbon dioxide partial pressure(PaCO_(2))were decreased(P<0.05).After treatment,the levels of PaO_(2),FEV_(1)and FEV_(1)/FVC in the observation group were higher than those in the control group(P<0.05),and the levels of TNF-α,hs-CRP,ET-1,NT-proBNP,cTnI and BNP in serum as well as PaCO_(2)were lower(P<0.05).During treatment,there was no significant difference being found in the comparison of the incidences of adverse reactions between the two groups(P>0.05).Conclusion:The therapy of Danhong injection combined with phentolamine mesylate for patients with chronic pulmonary heart disease can effectively relieve their blood gas indexes and lung function,reduce the levels of inflammatory factors,and improve their heart function.

关 键 词：慢性肺源性心脏病 丹红注射液 甲磺酸酚妥拉明 肺功能 N-末端脑钠素前体 

分 类 号：R541.5[医药卫生—心血管疾病]