CD4+T cells memorize obesity and promote weight regain  

作　　者：Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animal for Disease Study,Model Animal Research Center,Nanjing Biomedical Research Institute,Nanjing University,12 Xuefu Road,Pukou District,Nanjing,Jiangsu 210061,China [2]Institute of Immunology,Program in Molecular and Cellular Biology,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310058,China

出　　处：《Cellular & Molecular Immunology》2018年第6期630-639,共10页中国免疫学杂志（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Grant 31301217);the Ministry of Science and Technology of China(Grants 2015BAI08B02 and 2014BAI02B01).

摘　　要：Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain.

关 键 词：CD4+T cell IMMUNODEFICIENCY METABOLISM obesity memory weight regain 

分 类 号：R58[医药卫生—内分泌]