李兰治疗不寐用药规律分析  

Analysis of LI Lan’s Medication Regularity in Treating Insomnia

作　　者：廖前花 李兰(指导) LIAO Qianhua;LI Lan(Graduate College of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,China;不详)

机构地区：[1]贵州中医药大学研究生院,贵州贵阳550001 [2]不详

出　　处：《山东中医药大学学报》2021年第4期518-523,共6页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家中医药管理局第二届国医大师传承工作室建设项目(批文号:国中医人教发[2015]24号);国家中医药管理局第三批全国优秀中医临床人才研修项目(批文号:国中医人教发[2012]148号)。

摘　　要：目的:通过数据挖掘方法总结李兰治疗不寐的用药组方规律及辨治经验。方法:筛选2018年1月至2020年4月李兰门诊治疗的不寐病案,借助Excel表整理基础数据,应用SPSS 24.0统计软件进行频次和聚类分析,使用数据挖掘软件对用药进行关联规则分析,总结李兰治疗不寐的用药组方规律。结果:通过筛选得出的248首方剂中包含152味药物,李兰治疗不寐用药频次≥30的药物有酸枣仁、郁金、川芎、佛手、珍珠母等。根据复杂网络分析,核心药物组合有5组,体现了重镇安神、健脾祛湿、宽胸化痰、养心安神、疏肝理气辨证特色。结论:李兰主要从心、肝、脾、肾论治不寐,痰热湿瘀内阻为实,气机不畅贯穿其中,不寐往往多脏同病,病机以肝肾阴亏、心脾两虚、肝血不足为主;扶正祛邪,多脏同治,如肝肾、心脾、心肝同治为法,兼以清热化痰、清热利湿、通利三焦祛邪、疏肝活血、宣畅气机。Objective:To summarize LI Lan’s medication and prescription regularity and experience in the differentiation and treatment of insomnia by data mining method.Methods:The insomnia medical records of LI Lan’s outpatient from January 2018 to April 2020 were screened.Excel was used to sort out the basic data,SPSS 24.0 statistical software was used for frequency and cluster analysis.Data mining software was used to analyze the association rule of the medication,and summarize LI Lan’s medication and prescription regularity for the treatment of insomnia.Results:Total 152 medicinals contained in 248 prescriptions were screened,and it was concluded that the medicinals used by LI Lan for the treatment of insomnia with frequency≥30 included:Suanzaoren(Ziziphi Spinosae Semen),Yujin(Curcumae Radix),Chuanxiong(Chuanxiong Rhizoma),Foshou(Citri Sarcodactylis Fructus)and Zhenzhumu(Margaritifera Concha),etc.According to the complex network analysis,there were 5 groups of core medicinal combinations for the treatment of insomnia,which embodied the characteristics of syndrome differentiation of tranquilizing mind with heavy sedatives,invigorating spleen and expelling dampness,smoothing the chest and resolving phlegm,nourishing heart and tranquilizing mind,and soothing liver and regulating qi.Conclusions:LI Lan treats insomnia mainly from heart,liver,spleen,and kidneys.The internal obstruction of phlegm,heat,dampness and blood stasis is excess,with unsmoothness of qi movement.The disease involving multiple organs is common seen,liver-kidney yin deficiency,deficiency of heart and spleen,and insufficiency of liver blood are the main pathogenesis.Treatment of reinforcing healthy qi and expelling pathogens involves multiple organs,such as:treating liver and kidney,heart and spleen,heart and liver at the same time,combined by clearing heat and resolving phlegm,clearing heat and draining dampness,expelling pathogens from the triple energizer,soothing liver and activating blood,smoothing qi movement.

关 键 词：数据挖掘 李兰 不寐 肝肾阴亏 心脾两虚 痰热湿浊 益肾疏肝健脾 养心安神 清热利湿 

分 类 号：R256.23[医药卫生—中医内科学] R2-03[医药卫生—中医学]