血栓弹力图与常规凝血功能检测在早期复发性流产患者凝血功能中的应用效果  

Application effect of thromboelastogram and routine coagulation function test in coagulation function of early recurrent miscarriage patients

作　　者：徐海霞[1,2] 伊碧霞[1,2] 徐攀[1,2] 项美姣[1,2] XU Haixia;YI Bixia;XU Pan;XIANG Meijiao(Department of Obstetrics and Gynecology,Jinhua City People′s Hospital,Jinhua 321000,China;Intensive Care Unit,Jinhua City People′s Hospital,Jinhua 321000 China)

机构地区：[1]浙江省金华市人民医院妇产科,浙江金华321000 [2]浙江省金华市人民医院ICU,浙江金华321000

出　　处：《中国现代医生》2021年第16期79-82,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2019KY746)。

摘　　要：目的探究血栓弹力图和常规凝血功能检测在早期复发性流产患者的应用效果。方法选取2018年2月至2019年3月金华市人民医院妇产科收治的复发性流产患者80例作为观察组,另选取同期正常生育期孕妇80例作为对照组。两组患者均进行常规凝血功能检测及血栓弹力图检测,对比两组患者检测结果。结果观察组患者常规凝血功能检测值中活化部分凝血活酶时间(APTT)低于对照组,观察组患者纤维蛋白原(FIB)、D-二聚体(DD)均高于对照组(t=2.403,7.050,1.024,0.308,0.168、P=0.017,0.000,0.307,0.758,0.867);两组患者凝血酶原时间(PT)、凝血酶时间(TT)及血小板计数(PLT)比较,差异无统计学意义(P>0.05);观察组患者血栓弹力图检测值中凝血反应时间(R值)、血凝块形成时间(K值)均低于对照组,观察组凝血形成速率(Angle角)、最大振幅(MA值)、凝血指数(CI值)均明显高于对照组患者(t=11.408,7.553,15.925,4.059,15.292、P=0.000);观察组患者中,R值与APTT呈正相关、R值与DD呈负相关、K值与FIB、PLT均呈负相关、Angle角、MA值、CI值均与FIB、PLT呈正相关(P<0.05)。结论早期复发性流产患者处于高凝状态;血栓弹力图和常规凝血功能检测与血小板计数存在相关性。监测血栓弹性成像有助于指导早期复发性流产患者接受抗血小板治疗。Objective To explore the effect of thromboelastography and routine coagulation function test in coagulation function of patients with early recurrent miscarriage.Methods From February 2018 to March 2019,80 patients with recurrent miscarriage admitted to the Department of Obstetrics and Gynecology of Jinhua People′s Hospital were selected as the observation group,and 80 pregnant women with normal childbearing during the same period were selected as the control group.Both groups of patients underwent routine coagulation function test and thromboelastography test.The test results of the two groups of patients were compared.Results The activated partial thromboplastin time(APTT)in the routine coagulation function test values of the observation group was lower than that of the control group,and the fibrinogen(FIB)and D-dimer(DD)of the observation group were higher than those of the control group(t=2.403,7.050,1.024,0.308,0.168,P=0.017,0.000,0.307,0.758,0.867).There was no statistical difference in prothrombin time(PT),thrombin time(TT)and platelet count(PLT)between the two groups(P>0.05).The coagulation reaction time(R value)and clot formation time(K value)in the thromboelastogram test values of the observation group were lower than those of the control group,and the coagulation rate(Angle angle),the maximum amplitude(MA value)and the coagulation index(CI value)of the observation group were significantly higher than those of the control group(t=11.408,7.553,15.925,4.059,15.292,P=0.000).In the observation group,R value was positively correlated with APTT and negatively correlated with DD,K value was negatively correlated with FIB and PLT,Angle angle,MA value,and CI value were all positively correlated with FIB and PLT(P<0.05).Conclusion Patients with early recurrent miscarriage are in a hypercoagulable state.Thromboelastography and routine coagulation function tests are correlated with platelet counts.Monitoring thrombus elastography can help guide patients with early recurrent miscarriage to receive antiplatelet the

关 键 词：血栓弹力图 常规凝血功能检测 复发性流产 凝血功能 血小板计数 凝血酶时间 凝血形成速率 凝血指数 

分 类 号：R687.3[医药卫生—骨科学]