Cbl-b及肠道菌群在慢性阻塞性肺疾病患者营养不良中的研究进展  

Research progress of Cbl-b and intestinal flora in chronic obstructive pulmonary disease malnutrition

作　　者：李狄非 卢文菊[1] 郑则广[1] Li Difei;Lu Wenjyu;Zheng Zeguang(State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院广州呼吸健康研究院,呼吸疾病国家重点实验室,国家呼吸系统疾病临床医学研究中心,510120

出　　处：《国际呼吸杂志》2021年第12期931-935,共5页International Journal of Respiration

基　　金：国家自然科学基金(81873408);国家十三五重点研发项目(2016YFC1304600);国家重点实验室课题(B195004001009)。

摘　　要：慢性阻塞性肺疾病(COPD)营养不良的问题越来越受到广大临床专家及科研人员的重视。目前已有部分研究深入探索COPD营养不良的发生机制。肠道菌群是当前的研究热点,肠道菌群失衡对于机体营养状态具有重大的影响。Cbl-b与自身免疫失衡引起的炎症性疾病关联密切,其可能在引起肠道促炎细菌及抗炎细菌平衡上起重要作用。也有文献报道Cbl-b与骨骼肌萎缩密切相关,表明其与机体营养状态有联系,而COPD慢性缺氧也存在骨骼肌适应性萎缩的表现。本文总结COPD营养不良的发生机制,并就肠道菌群及Cbl-b与COPD营养不良关系的相关研究进行综述。The problem of malnutrition in chronic obstructive pulmonary disease(COPD)is raising more and more attention from clinical experts and researchers.At present,some studies have explored deeply about the mechanism of COPD malnutrition.Intestinal flora is the current popular research area,and the imbalance of intestinal flora has a significant impact on the nutritional status of the body.Cbl-b is closely related to inflammatory diseases caused by autoimmune imbalance,and it may play an important role in helping the balance of intestinal pro-inflammatory and anti-inflammatory bacteria.It has been reported that Cbl-b is closely related to skeletal muscle atrophy,indicating that it is related to the body's nutritional status,and COPD hypoxia also leads to skeletal muscle adaptive atrophy.This article summarizes the mechanism of COPD malnutrition,and reviews the relationship of intestinal flora as well as Cbl-b in COPD malnutrition.

关 键 词：CBL-B 肠道菌群 肺疾病 慢性阻塞性 营养不良 

分 类 号：R563.9[医药卫生—呼吸系统]