Multi-omics: Opportunities for research on mechanism of type 2 diabetes mellitus  

作　　者：Shuai Wang Hui Yong Xiao-Dong He 

机构地区：[1]Institute of Toxicology,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong Province,China [2]Department of Physical and Chemical Inspection,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong Province,China

出　　处：《World Journal of Diabetes》2021年第7期1070-1080,共11页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by Grant from International Joint Usage/Research Center,the Institute of Medical Science,the University of Tokyo,No.New-2020-K2012;and Open Project of Shandong Provincial Key Laboratory of Infection and Immunity,No.2.

摘　　要：Type 2 diabetes mellitus(T2DM)is a burdensome global disease.In-depth understanding of its mechanism will help to optimize diagnosis and treatment,which reduces the burden.Multi-omics research has unparalleled advantages in contributing to the overall understanding of the mechanism of this chronic metabolic disease.In the past two decades,the study of multi-omics on T2DMrelated intestinal flora perturbation and plasma dyslipidemia has shown tremendous potential and is expected to achieve major breakthroughs.The regulation of intestinal flora in diabetic patients has been confirmed by multiple studies.The use of metagenomics,16S RNA sequencing,and metabolomics has comprehensively identified the overall changes in the intestinal flora and the metabolic disturbances that could directly or indirectly participate in the intestinal flora-host interactions.Lipidomics combined with other“omics”has characterized lipid metabolism disorders in T2DM.The combined application and crossvalidation of multi-omics can screen for dysregulation in T2DM,which will provide immense opportunities to understand the mechanisms behind T2DM.

关 键 词：Type 2 diabetes mellitus Gastrointestinal microbiome Intestinal flora Lipid metabolism disorders DYSLIPIDEMIAS Metabolomics 

分 类 号：R587.1[医药卫生—内分泌]