程序性死亡受体1在HIV感染和防治中的作用研究进展  

Research progress in role of programmed cell death-1 on HIV infection, prevention and treatment

作　　者：刘晓晓 庄敏[1] 凌虹[1] 王甲业[1] Liu Xiaoxiao;Zhuang Min;Ling Hong;Wang Jiaye(Department of Microbiology,Harbin Medical University,Heilongjiang Provincial Key Laboratory for Infection and Immunity,Heilongjiang Provincial Key Laboratory of Pathogen Biology,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学微生物学教研室,黑龙江省感染与免疫重点实验室,黑龙江省普通高校病原生物学重点实验室,150081

出　　处：《中华微生物学和免疫学杂志》2021年第6期473-478,共6页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(81601755);黑龙江省自然科学基金(QC2016110)。

摘　　要：程序性死亡受体1(programmed cell death-1,PD-1)是细胞表面的一种免疫抑制分子,与配体PD-L1或PD-L2相互作用,负向调控细胞和体液免疫应答。人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染后,PD-1在感染者外周血淋巴细胞表面表达上调,高水平表达的PD-1不仅影响病毒对靶细胞的易感性和宿主的抗病毒免疫应答能力,还影响抗逆转录病毒治疗效果。体外阻断PD-1/PD-L通路可改善宿主细胞对HIV的特异性免疫应答水平,已作为辅助手段用于抗病毒治疗和HIV疫苗的研究中。本文概述了PD-1在HIV感染和防治中的研究进展。Programmed death-1(PD-1)is an immunosuppressive molecule on the surface of several cells,and functions as a negative regulatory factor in cellular and humoral immune responses via interaction with its ligand PD-L1 or PD-L2.The expression of PD-1 on the peripheral blood lymphocytes of human immunodeficiency virus(HIV)infected people is commonly up-regulated,which not only affects the susceptibility of the virus to target cells and the host′s antiviral immune response,but also affects the effect of antiretroviral therapy.In vitro blocking PD-1/PD-L pathway showed improved HIV-specific immune response of host cells,and PD-1 blockade and/or PD-L1 blockade have been used as an auxiliary means to enhance the efficacy of antiviral therapy and HIV vaccines.This article reviews the progress of the studies on PD-1 in HIV infection,prevention and treatment.

关 键 词：程序性死亡受体1 人类免疫缺陷病毒 感染 防治 

分 类 号：R512.91[医药卫生—内科学]